Serine-arginine protein kinase 1 promotes a cancer stem cell-like phenotype through activation of Wnt/ß-catenin signalling in NSCLC.

Gong, Liyun; Song, Junwei; Lin, Xi; Wei, Fakai; Zhang, Cuicui; Wang, Zimei; Zhu, Jinrong; Wu, Shu; Chen, Yu; Liang, Jin; Fu, XiaoYuan; Lu, Junqiang; Zhou, Chunhui; Song, Libing

Gong, Liyun; Song, Junwei; Lin, Xi; Wei, Fakai; Zhang, Cuicui; Wang, Zimei; Zhu, Jinrong; Wu, Shu; Chen, Yu; Liang, Jin; Fu, XiaoYuan; Lu, Junqiang; Zhou, Chunhui; Song, Libing.

Afiliação

Gong L; Key Laboratory of Translational Medicine of Tumor, Department of Biochemistry and Molecular Biology, Health Science Center, Shenzhen University, Shenzhen, China.
Song J; Key Laboratory of Translational Medicine of Tumor, Department of Biochemistry and Molecular Biology, Health Science Center, Shenzhen University, Shenzhen, China.
Lin X; State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, China.
Wei F; Department of Biochemistry, Sun Yat-sen University, Guangzhou, China.
Zhang C; State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, China.
Wang Z; Key Laboratory of Translational Medicine of Tumor, Department of Biochemistry and Molecular Biology, Health Science Center, Shenzhen University, Shenzhen, China.
Zhu J; Key Laboratory of Translational Medicine of Tumor, Department of Biochemistry and Molecular Biology, Health Science Center, Shenzhen University, Shenzhen, China.
Wu S; Key Laboratory of Translational Medicine of Tumor, Department of Biochemistry and Molecular Biology, Health Science Center, Shenzhen University, Shenzhen, China.
Chen Y; Department of Biochemistry, Sun Yat-sen University, Guangzhou, China.
Liang J; State Key Laboratory of Oncology in Southern China, Department of Experimental Research, Cancer Center, Sun Yat-sen University, Guangzhou, China.
Fu X; Key Laboratory of Translational Medicine of Tumor, Department of Biochemistry and Molecular Biology, Health Science Center, Shenzhen University, Shenzhen, China.
Lu J; Key Laboratory of Translational Medicine of Tumor, Department of Biochemistry and Molecular Biology, Health Science Center, Shenzhen University, Shenzhen, China.
Zhou C; The Affiliated Hospital of Shenzhen University, Shenzhen, China.
Song L; The Affiliated Hospital of Shenzhen University, Shenzhen, China.

J Pathol ; 240(2): 184-96, 2016 10.

Article em En | MEDLINE | ID: mdl-27391422

Assuntos

Carcinoma Pulmonar de Células não Pequenas/metabolismo; Neoplasias Pulmonares/metabolismo; Células-Tronco Neoplásicas/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Via de Sinalização Wnt/fisiologia; Animais; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma Pulmonar de Células não Pequenas/patologia; Linhagem Celular Tumoral; Proliferação de Células/genética; Humanos; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Masculino; Camundongos; Células-Tronco Neoplásicas/patologia; Fenótipo; Proteínas Serina-Treonina Quinases/genética

Palavras-chave

NSCLC; SRPK1; Wnt/ß-catenin signalling; stem cell-like phenotype

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Proteínas Serina-Treonina Quinases / Carcinoma Pulmonar de Células não Pequenas / Via de Sinalização Wnt / Neoplasias Pulmonares Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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