Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells.

Fujiwara, Yukio; Horlad, Hasita; Shiraishi, Daisuke; Tsuboki, Junko; Kudo, Rino; Ikeda, Tsuyoshi; Nohara, Toshihiro; Takeya, Motohiro; Komohara, Yoshihiro

Fujiwara, Yukio; Horlad, Hasita; Shiraishi, Daisuke; Tsuboki, Junko; Kudo, Rino; Ikeda, Tsuyoshi; Nohara, Toshihiro; Takeya, Motohiro; Komohara, Yoshihiro.

Afiliação

Fujiwara Y; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Horlad H; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Shiraishi D; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Tsuboki J; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Kudo R; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Ikeda T; Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
Nohara T; Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
Takeya M; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Komohara Y; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Mol Nutr Food Res ; 60(11): 2467-2480, 2016 11.

Article em En | MEDLINE | ID: mdl-27393711

Assuntos

Anticarcinógenos/isolamento & purificação; Anticarcinógenos/farmacologia; Imunossupressores/isolamento & purificação; Imunossupressores/farmacologia; Células Mieloides/efeitos dos fármacos; Cebolas/química; Sulfóxidos/isolamento & purificação; Sulfóxidos/farmacologia; Enxofre/química; Tiofenos/isolamento & purificação; Tiofenos/farmacologia; Animais; Anticarcinógenos/química; Cisplatino/farmacologia; Humanos; Tolerância Imunológica/efeitos dos fármacos; Imunossupressores/química; Neoplasias Pulmonares/patologia; Macrófagos/efeitos dos fármacos; Camundongos; Fator de Transcrição STAT3/metabolismo; Sulfóxidos/química; Tiofenos/química

Palavras-chave

MDSCs; Macrophages; Onionin A; Stat3; Tumor cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfóxidos / Enxofre / Tiofenos / Anticarcinógenos / Cebolas / Células Mieloides / Imunossupressores Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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