Folic Acid-Functionalized Polythiophene for Targeted Cellular Imaging.
J Nanosci Nanotechnol
; 16(1): 189-95, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-27398444
ABSTRACT
Polythiophene containing pendant N-hydroxysuccinimide (NHS) ester groups was reacted with poly(ethylene glycol) (PEG) and oleylamine, which was subsequently modified with folic acid to prepare a targeting fluorescent cellular imaging probe. The amphiphilic character of the folic acid-functionalized polythiophene induced the formation of nanoparticles with an average diameter of 95.3 nm in water. This polymer shows good photostability and low toxicity toward KB cells at a high concentration (100 µg/mL), which meets the crucial requirement for cellular imaging and other biological applications. The folic acid-functionalized polythiophene could be internalized efficiently into KB cells and accumulated in the cytoplasm to yield bright fluorescence, indicating that it is a good candidate material for the fluorescence imaging of living cells.
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Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Tiofenos
/
Teste de Materiais
/
Sistemas de Liberação de Medicamentos
/
Nanopartículas
/
Ácido Fólico
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article