Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity.

Gai, Zhibo; Visentin, Michele; Hiller, Christian; Krajnc, Evelin; Li, Tongzhou; Zhen, Junhui; Kullak-Ublick, Gerd A

Gai, Zhibo; Visentin, Michele; Hiller, Christian; Krajnc, Evelin; Li, Tongzhou; Zhen, Junhui; Kullak-Ublick, Gerd A.

Afiliação

Gai Z; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Visentin M; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Hiller C; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Krajnc E; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Li T; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Zhen J; Department of Pathology, School of Medicine, Shandong University, Jinan, China.
Kullak-Ublick GA; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland gerd.kullak@usz.ch.

Antimicrob Agents Chemother ; 60(9): 5573-80, 2016 09.

Article em En | MEDLINE | ID: mdl-27401566

Assuntos

Gentamicinas/efeitos adversos; Nefropatias/induzido quimicamente; Nefropatias/metabolismo; Rim/efeitos dos fármacos; Rim/metabolismo; Proteínas de Transporte de Cátions Orgânicos/metabolismo; Animais; Linhagem Celular; Dieta Hiperlipídica; Feminino; Gentamicinas/farmacologia; Células HEK293; Humanos; Cinética; Masculino; Metformina/farmacologia; Camundongos; Camundongos Endogâmicos C57BL; Pessoa de Meia-Idade; Obesidade/metabolismo; RNA Mensageiro/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Gentamicinas / Proteínas de Transporte de Cátions Orgânicos / Rim / Nefropatias Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google