Detectable Tenofovir Levels in Breast-Feeding Infants of Mothers Exposed to Topical Tenofovir.
Antimicrob Agents Chemother
; 60(9): 5616-9, 2016 09.
Article
em En
| MEDLINE
| ID: mdl-27401570
ABSTRACT
Lactation studies are necessary evaluations of medications for reproductive-age women. We evaluated pharmacokinetics (PK), pharmacodynamics, safety, and adherence profiles associated with 7 days of 1% tenofovir (TFV) vaginal gel use during lactation. Tenofovir levels (maternal/infant serum, milk) and anti-HIV activity (milk), adverse events (AEs), and adherence were measured for 17 HIV-1-seronegative breast-feeding mother-infant pairs. Tenofovir use was well-tolerated and detected at low levels in maternal serum, milk, and infant serum but demonstrated no anti-HIV activity in milk.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fármacos Anti-HIV
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Tenofovir
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Leite Humano
Limite:
Adult
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Female
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Humans
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Infant
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article