Catalytic Macrocyclization Strategies Using Continuous Flow: Formal Total Synthesis of Ivorenolide A.
J Org Chem
; 81(15): 6750-6, 2016 08 05.
Article
em En
| MEDLINE
| ID: mdl-27404899
ABSTRACT
A formal total synthesis of ivorenolide A has been accomplished employing a Z-selective olefin cross metathesis and a macrocyclic Glaser-Hay coupling as key steps. The macrocyclization protocol employed a phase separation/continuous flow manifold whose advantages include catalysis, fast reaction times, high concentrations, and facile scale-up.
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MEDLINE
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En
Ano de publicação:
2016
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Article