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Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates.
Zhang, Donglu; Yu, Shang-Fan; Ma, Yong; Xu, Keyang; Dragovich, Peter S; Pillow, Thomas H; Liu, Luna; Del Rosario, Geoffrey; He, Jintang; Pei, Zhonghua; Sadowsky, Jack D; Erickson, Hans K; Hop, Cornelis E C A; Khojasteh, S Cyrus.
Afiliação
  • Zhang D; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California zhang.donglu@gene.com.
  • Yu SF; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California.
  • Ma Y; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California.
  • Xu K; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California.
  • Dragovich PS; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California.
  • Pillow TH; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California.
  • Liu L; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California.
  • Del Rosario G; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California.
  • He J; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California.
  • Pei Z; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California.
  • Sadowsky JD; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California.
  • Erickson HK; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California.
  • Hop CE; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California.
  • Khojasteh SC; Drug Metabolism and Pharmacokinetics (D.Z., Y.M., C.E.C.A.H, S.C.K.), Translational Oncology (S.Y., G.D.R.), BioAnalytical Sciences (K.X., L.L., J.H.), Discovery Chemistry (P.S.D., T.H.P., Z.P.), Protein Chemistry (J.D.S., H.K.E.), Genentech, South San Francisco, California.
Drug Metab Dispos ; 44(9): 1517-23, 2016 09.
Article em En | MEDLINE | ID: mdl-27417182
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirróis / Benzodiazepinas / Imunoconjugados / Anticorpos Monoclonais Humanizados / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirróis / Benzodiazepinas / Imunoconjugados / Anticorpos Monoclonais Humanizados / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article