Repeated OnabotulinumtoxinA Treatment of Glabellar Lines at Rest Over Three Treatment Cycles.
Dermatol Surg
; 42(9): 1094-101, 2016 Sep.
Article
em En
| MEDLINE
| ID: mdl-27427996
ABSTRACT
BACKGROUND:
OnabotulinumtoxinA has demonstrated the ability to eliminate mild glabellar lines at rest; however, less is known regarding the effect of repeat treatment on more severe lines at rest.OBJECTIVE:
To assess the effect of repeated onabotulinumtoxinA treatment for reduction of glabellar lines at rest.METHODS:
Subjects 18 to 75 years old with at least mild glabellar lines at rest, as assessed by the validated Facial Wrinkle Scale (FWS) with photonumeric guide (score ≥ 1), received 3 treatments of 20 U onabotulinumtoxinA 4 months apart (N = 225). "Response" was defined as elimination of glabellar lines at rest (FWS score = 0) at any time point (Days 7, 30, 60, 90, and 120). Effect of treatment cycle on response was analyzed using repeated measures logistic regressions (p < .05).RESULTS:
Most subjects were female (85%) and white (88%) (age range 35-54 years). The likelihood of significant response was as follows for all subjects combined (odds ratio [OR] 1.31), for subjects with mild resting lines at baseline (OR 1.49), and for older women (≥55 years) with mild resting lines at baseline (OR 2.22). Of all subjects, 76% responded after 1 treatment, and 45% responded in all 3 cycles.CONCLUSION:
Subjects repeatedly treated with onabotulinumtoxinA showed progressive improvement in glabellar lines at rest.
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Base de dados:
MEDLINE
Assunto principal:
Envelhecimento da Pele
/
Toxinas Botulínicas Tipo A
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Fármacos Neuromusculares
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article