Fasiglifam (TAK-875) has dual potentiating mechanisms via G&#945;q-GPR40/FFAR1 signaling branches on glucose-dependent insulin secretion.

Sakuma, Kensuke; Yabuki, Chiori; Maruyama, Minoru; Abiru, Akiko; Komatsu, Hidetoshi; Negoro, Nobuyuki; Tsujihata, Yoshiyuki; Takeuchi, Koji; Habata, Yugo; Mori, Masaaki

Fasiglifam (TAK-875) has dual potentiating mechanisms via Gαq-GPR40/FFAR1 signaling branches on glucose-dependent insulin secretion.

Sakuma, Kensuke; Yabuki, Chiori; Maruyama, Minoru; Abiru, Akiko; Komatsu, Hidetoshi; Negoro, Nobuyuki; Tsujihata, Yoshiyuki; Takeuchi, Koji; Habata, Yugo; Mori, Masaaki.

Afiliação

Sakuma K; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
Yabuki C; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
Maruyama M; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
Abiru A; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
Komatsu H; Central Nervous System Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
Negoro N; Inflammation Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
Tsujihata Y; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
Takeuchi K; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
Habata Y; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
Mori M; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.