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Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.
Tang, Haifeng; Zhu, Yuping; Teumelsan, Nardos; Walsh, Shawn P; Shahripour, Aurash; Priest, Birgit T; Swensen, Andrew M; Felix, John P; Brochu, Richard M; Bailey, Timothy; Thomas-Fowlkes, Brande; Pai, Lee-Yuh; Hampton, Caryn; Corona, Aaron; Hernandez, Melba; Metzger, Joseph; Forrest, Michael; Zhou, Xiaoyan; Owens, Karen; Tong, Vincent; Parmee, Emma; Roy, Sophie; Kaczorowski, Gregory J; Yang, Lihu; Alonso-Galicia, Magdalena; Garcia, Maria L; Pasternak, Alexander.
Afiliação
  • Tang H; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Zhu Y; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Teumelsan N; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Walsh SP; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Shahripour A; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Priest BT; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Swensen AM; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Felix JP; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Brochu RM; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Bailey T; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Thomas-Fowlkes B; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Pai LY; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Hampton C; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Corona A; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Hernandez M; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Metzger J; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Forrest M; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Zhou X; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Owens K; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Tong V; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Parmee E; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Roy S; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Kaczorowski GJ; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Yang L; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Alonso-Galicia M; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Garcia ML; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
  • Pasternak A; Departments of Discovery Chemistry, Ion Channels, In Vivo Pharmacology, Cardiorenal, and Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.
ACS Med Chem Lett ; 7(7): 697-701, 2016 Jul 14.
Article em En | MEDLINE | ID: mdl-27437080
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article