Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure.

Schnapp, Gisela; Klein, Thomas; Hoevels, Yvette; Bakker, Remko A; Nar, Herbert

Schnapp, Gisela; Klein, Thomas; Hoevels, Yvette; Bakker, Remko A; Nar, Herbert.

Afiliação

Schnapp G; Department of Lead Identification and Optimization Support and Department of CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG , Biberach 88397, Germany.
Klein T; Department of Lead Identification and Optimization Support and Department of CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG , Biberach 88397, Germany.
Hoevels Y; Department of Lead Identification and Optimization Support and Department of CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG , Biberach 88397, Germany.
Bakker RA; Department of Lead Identification and Optimization Support and Department of CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG , Biberach 88397, Germany.
Nar H; Department of Lead Identification and Optimization Support and Department of CardioMetabolic Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG , Biberach 88397, Germany.

J Med Chem ; 59(16): 7466-77, 2016 Aug 25.

Article em En | MEDLINE | ID: mdl-27438064

Assuntos

Dipeptidil Peptidase 4/metabolismo; Inibidores da Dipeptidil Peptidase IV/farmacologia; Termodinâmica; Sítios de Ligação; Inibidores da Dipeptidil Peptidase IV/química; Relação Dose-Resposta a Droga; Humanos; Cinética; Modelos Moleculares; Estrutura Molecular; Relação Estrutura-Atividade; Ressonância de Plasmônio de Superfície

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Termodinâmica / Dipeptidil Peptidase 4 / Inibidores da Dipeptidil Peptidase IV Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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