Target deletion of complement component 9 attenuates antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock in mice.

Fu, Xiaoyan; Ju, Jiyu; Lin, Zhijuan; Xiao, Weiling; Li, Xiaofang; Zhuang, Baoxiang; Zhang, Tingting; Ma, Xiaojun; Li, Xiangyu; Ma, Chao; Su, Weiliang; Wang, Yuqi; Qin, Xuebin; Liang, Shujuan

Fu, Xiaoyan; Ju, Jiyu; Lin, Zhijuan; Xiao, Weiling; Li, Xiaofang; Zhuang, Baoxiang; Zhang, Tingting; Ma, Xiaojun; Li, Xiangyu; Ma, Chao; Su, Weiliang; Wang, Yuqi; Qin, Xuebin; Liang, Shujuan.

Afiliação

Fu X; Key Lab for Immunology in Universities of Shandong Province, School of Clinical Medicine, Weifang Medical University, Weifang, 261053, P.R.China.
Ju J; Key Lab for Immunology in Universities of Shandong Province, School of Clinical Medicine, Weifang Medical University, Weifang, 261053, P.R.China.
Lin Z; Key Lab for Immunology in Universities of Shandong Province, School of Clinical Medicine, Weifang Medical University, Weifang, 261053, P.R.China.
Xiao W; Key Lab for Immunology in Universities of Shandong Province, School of Clinical Medicine, Weifang Medical University, Weifang, 261053, P.R.China.
Li X; Key Lab for Immunology in Universities of Shandong Province, School of Clinical Medicine, Weifang Medical University, Weifang, 261053, P.R.China.
Zhuang B; Key Lab for Immunology in Universities of Shandong Province, School of Clinical Medicine, Weifang Medical University, Weifang, 261053, P.R.China.
Zhang T; Key Lab for Immunology in Universities of Shandong Province, School of Clinical Medicine, Weifang Medical University, Weifang, 261053, P.R.China.
Ma X; Key Lab for Immunology in Universities of Shandong Province, School of Clinical Medicine, Weifang Medical University, Weifang, 261053, P.R.China.
Li X; Key Lab for Immunology in Universities of Shandong Province, School of Clinical Medicine, Weifang Medical University, Weifang, 261053, P.R.China.
Ma C; Key Lab for Immunology in Universities of Shandong Province, School of Clinical Medicine, Weifang Medical University, Weifang, 261053, P.R.China.
Su W; Key Lab for Immunology in Universities of Shandong Province, School of Clinical Medicine, Weifang Medical University, Weifang, 261053, P.R.China.
Wang Y; Key Lab for Immunology in Universities of Shandong Province, School of Clinical Medicine, Weifang Medical University, Weifang, 261053, P.R.China.
Qin X; Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA19140, USA.
Liang S; Key Lab for Immunology in Universities of Shandong Province, School of Clinical Medicine, Weifang Medical University, Weifang, 261053, P.R.China.

Sci Rep ; 6: 30239, 2016 07 22.

Article em En | MEDLINE | ID: mdl-27444648

Assuntos

Complemento C5b/genética; Complemento C9/genética; Complexo de Ataque à Membrana do Sistema Complemento/genética; Inflamação/genética; Choque/genética; Animais; Anticorpos/imunologia; Anticorpos/metabolismo; Membrana Celular/genética; Membrana Celular/metabolismo; Complemento C5b/imunologia; Complemento C9/imunologia; Complexo de Ataque à Membrana do Sistema Complemento/química; Complexo de Ataque à Membrana do Sistema Complemento/imunologia; Proteínas do Sistema Complemento/genética; Proteínas do Sistema Complemento/imunologia; Proteínas do Sistema Complemento/metabolismo; Eritrócitos/imunologia; Eritrócitos/metabolismo; Hemólise/imunologia; Humanos; Inflamassomos/genética; Inflamassomos/imunologia; Inflamação/induzido quimicamente; Inflamação/imunologia; Inflamação/patologia; Lipopolissacarídeos/toxicidade; Camundongos; Camundongos Knockout; Choque/induzido quimicamente; Choque/imunologia; Choque/fisiopatologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Choque / Complemento C9 / Complexo de Ataque à Membrana do Sistema Complemento / Complemento C5b / Inflamação Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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