Cu(I) complexes of bis(methyl)(thia/selena) salen ligands: Synthesis, characterization, redox behavior and DNA binding studies.
Spectrochim Acta A Mol Biomol Spectrosc
; 171: 18-24, 2017 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-27458761
ABSTRACT
Mononuclear cuprous complexes 1 and 2, [{CH3E(o-C6H4)CH=NCH2}2Cu]ClO4; E=S/Se, have been synthesized by the reaction of bis(methyl)(thia/selena) salen ligands and [Cu(CH3CN)4]ClO4. Both the products were characterized by elemental analysis, ESI-MS, FT-IR, 1H/13C/77Se NMR, and cyclic voltammetry. The complexes possess tetrahedral geometry around metal center with the N2S2/N2Se2 coordination core. Cyclic voltammograms of complexes 1 and 2 displayed reversible anodic waves at E1/2=+0.08V and +0.10V, respectively, corresponding to the Cu(I)/Cu(II) redox couple. DNA binding studies of both the complexes were performed applying absorbance, fluorescence and molecular docking techniques. Competitive binding experiment of complexes with ct-DNA against ethidium bromide is performed to predict the mode of binding. The results indicate the groove binding mode of complexes 1 and 2 to DNA. The binding constants revealed the strong binding affinity of complexes towards ct-DNA.
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MEDLINE
Assunto principal:
Compostos Organometálicos
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DNA
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Cobre
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article