Identifying Novel Type ZBGs and Nonhydroxamate HDAC Inhibitors Through a SVM Based Virtual Screening Approach.

Liu, X H; Song, H Y; Zhang, J X; Han, B C; Wei, X N; Ma, X H; Cui, W K; Chen, Y Z

Liu, X H; Song, H Y; Zhang, J X; Han, B C; Wei, X N; Ma, X H; Cui, W K; Chen, Y Z.

Afiliação

Liu XH; Bioinformatics and Drug Design Group, Department of Pharmacy, National University of Singapore, Blk S16,Level 8, 3 Science Drive 2, Singapore 117543 phone: 65-6874-6877, fax: 65-6774-6756.
Song HY; Institute of Materials Research and Engineering, A*STAR, 3 Research Link, Singapore 117602.
Zhang JX; Bioinformatics and Drug Design Group, Department of Pharmacy, National University of Singapore, Blk S16,Level 8, 3 Science Drive 2, Singapore 117543 phone: 65-6874-6877, fax: 65-6774-6756.
Han BC; Bioinformatics and Drug Design Group, Department of Pharmacy, National University of Singapore, Blk S16,Level 8, 3 Science Drive 2, Singapore 117543 phone: 65-6874-6877, fax: 65-6774-6756.
Wei XN; Bioinformatics and Drug Design Group, Department of Pharmacy, National University of Singapore, Blk S16,Level 8, 3 Science Drive 2, Singapore 117543 phone: 65-6874-6877, fax: 65-6774-6756.
Ma XH; Bioinformatics and Drug Design Group, Department of Pharmacy, National University of Singapore, Blk S16,Level 8, 3 Science Drive 2, Singapore 117543 phone: 65-6874-6877, fax: 65-6774-6756.
Cui WK; Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543.
Chen YZ; Bioinformatics and Drug Design Group, Department of Pharmacy, National University of Singapore, Blk S16,Level 8, 3 Science Drive 2, Singapore 117543 phone: 65-6874-6877, fax: 65-6774-6756. phacyz@nus.edu.sg.

Mol Inform ; 29(5): 407-20, 2010 May 17.

Article em En | MEDLINE | ID: mdl-27463196

Palavras-chave

Computer aided drug design; Drug design; HDAC; In silico modeling; Inhibitors; Machine learning; Nonhydroxamate; Support vector machine; Virtual screening; Zinc binding group

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Ano de publicação: 2010 Tipo de documento: Article