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Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors.
Escuin-Ordinas, Helena; Li, Shuoran; Xie, Michael W; Sun, Lu; Hugo, Willy; Huang, Rong Rong; Jiao, Jing; de-Faria, Felipe Meira; Realegeno, Susan; Krystofinski, Paige; Azhdam, Ariel; Komenan, Sara Marie D; Atefi, Mohammad; Comin-Anduix, Begoña; Pellegrini, Matteo; Cochran, Alistair J; Modlin, Robert L; Herschman, Harvey R; Lo, Roger S; McBride, William H; Segura, Tatiana; Ribas, Antoni.
Afiliação
  • Escuin-Ordinas H; Division of Hematology/Oncology, Department of Medicine, University of California, Los Angeles (UCLA), 14-635 Factor Bldg, 10833 Le Conte Avenue, Los Angeles, California 90095, USA.
  • Li S; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles (UCLA), 7524 Boelter Hall, Los Angeles, California 90095, USA.
  • Xie MW; Division of Experimental Radiation Oncology, Department of Radiation Oncology, University of California, Los Angeles (UCLA), B3-109 CHS, Los Angeles, California 90095, USA.
  • Sun L; Division of Dermatology, Department of Medicine, University of California, Los Angeles (UCLA), 52-121 CHS and 13-942 Factor Bldg, Los Angeles, California 90095, USA.
  • Hugo W; Division of Dermatology, Department of Medicine, University of California, Los Angeles (UCLA), 52-121 CHS and 13-942 Factor Bldg, Los Angeles, California 90095, USA.
  • Huang RR; Department of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA), 924 Westwood Blvd. 730 and 1P-162 CHS, Los Angeles, California 90095, USA.
  • Jiao J; Department of Molecular and Medical Pharmacology, University of California, Los Angeles (UCLA), 329 Boyer Hall, Los Angeles, California 90095, USA.
  • de-Faria FM; Department of Biological Chemistry, University of California, Los Angeles (UCLA), 341 Boyer Hall, Los Angeles, California 90095, USA.
  • Realegeno S; Department of Molecular and Medical Pharmacology, University of California, Los Angeles (UCLA), 329 Boyer Hall, Los Angeles, California 90095, USA.
  • Krystofinski P; Department of Structural and Functional Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, 13083-970 Sao Paulo, Brazil.
  • Azhdam A; Department of Microbiology, Immunology &Molecular Genetics, University of California, Los Angeles (UCLA), 52-121 CHS, Los Angeles, California 90095, USA.
  • Komenan SM; Division of Hematology/Oncology, Department of Medicine, University of California, Los Angeles (UCLA), 14-635 Factor Bldg, 10833 Le Conte Avenue, Los Angeles, California 90095, USA.
  • Atefi M; Division of Hematology/Oncology, Department of Medicine, University of California, Los Angeles (UCLA), 14-635 Factor Bldg, 10833 Le Conte Avenue, Los Angeles, California 90095, USA.
  • Comin-Anduix B; Division of Surgical Oncology, Department of Surgery, 11-234 and 9-954 Factor Bldg, Los Angeles, California 90095, USA.
  • Pellegrini M; Division of Hematology/Oncology, Department of Medicine, University of California, Los Angeles (UCLA), 14-635 Factor Bldg, 10833 Le Conte Avenue, Los Angeles, California 90095, USA.
  • Cochran AJ; Division of Surgical Oncology, Department of Surgery, 11-234 and 9-954 Factor Bldg, Los Angeles, California 90095, USA.
  • Modlin RL; Jonsson Comprehensive Cancer Center, 10833 Le Conte Ave, Los Angeles, California 90024, USA.
  • Herschman HR; Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles (UCLA), 3000C Terasaki Life Sciences Bldg, Los Angeles, California 90095, USA.
  • Lo RS; Department of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA), 924 Westwood Blvd. 730 and 1P-162 CHS, Los Angeles, California 90095, USA.
  • McBride WH; Division of Dermatology, Department of Medicine, University of California, Los Angeles (UCLA), 52-121 CHS and 13-942 Factor Bldg, Los Angeles, California 90095, USA.
  • Segura T; Jonsson Comprehensive Cancer Center, 10833 Le Conte Ave, Los Angeles, California 90024, USA.
  • Ribas A; Department of Molecular and Medical Pharmacology, University of California, Los Angeles (UCLA), 329 Boyer Hall, Los Angeles, California 90095, USA.
Nat Commun ; 7: 12348, 2016 08 01.
Article em En | MEDLINE | ID: mdl-27476449
Assuntos
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas B-raf/antagonistas & inibidores; Pele/efeitos dos fármacos; Cicatrização/efeitos dos fármacos; Administração Tópica; Animais; Carcinogênese/efeitos dos fármacos; Carcinogênese/patologia; Carcinógenos/toxicidade; Carcinoma de Células Escamosas/induzido quimicamente; Carcinoma de Células Escamosas/tratamento farmacológico; Carcinoma de Células Escamosas/epidemiologia; Carcinoma de Células Escamosas/patologia; Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Feminino; Humanos; Incidência; Indóis/farmacologia; Indóis/uso terapêutico; Queratinócitos; Camundongos; Camundongos Endogâmicos BALB C; Quinases de Proteína Quinase Ativadas por Mitógeno/antagonistas & inibidores; Proteínas Quinases Ativadas por Mitógeno/metabolismo; Neoplasias Experimentais/induzido quimicamente; Neoplasias Experimentais/tratamento farmacológico; Neoplasias Experimentais/epidemiologia; Neoplasias Experimentais/patologia; Inibidores de Proteínas Quinases/uso terapêutico; Piridonas/farmacologia; Piridonas/uso terapêutico; Pirimidinonas/farmacologia; Pirimidinonas/uso terapêutico; Pele/metabolismo; Pele/patologia; Neoplasias Cutâneas/induzido quimicamente; Neoplasias Cutâneas/tratamento farmacológico; Neoplasias Cutâneas/epidemiologia; Neoplasias Cutâneas/patologia; Sulfonamidas/farmacologia; Sulfonamidas/uso terapêutico; Resultado do Tratamento; Vemurafenib
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pele / Cicatrização / Sistema de Sinalização das MAP Quinases / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases Tipo de estudo: Incidence_studies / Prognostic_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pele / Cicatrização / Sistema de Sinalização das MAP Quinases / Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases Tipo de estudo: Incidence_studies / Prognostic_studies Idioma: En Ano de publicação: 2016 Tipo de documento: Article