Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS.

Amin, Ehsan; Jaiswal, Mamta; Derewenda, Urszula; Reis, Katarina; Nouri, Kazem; Koessmeier, Katja T; Aspenström, Pontus; Somlyo, Avril V; Dvorsky, Radovan; Ahmadian, Mohammad R

Amin, Ehsan; Jaiswal, Mamta; Derewenda, Urszula; Reis, Katarina; Nouri, Kazem; Koessmeier, Katja T; Aspenström, Pontus; Somlyo, Avril V; Dvorsky, Radovan; Ahmadian, Mohammad R.

Afiliação

Amin E; From the Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf, Germany.
Jaiswal M; From the Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf, Germany.
Derewenda U; the Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, and.
Reis K; the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Nouri K; From the Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf, Germany.
Koessmeier KT; From the Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf, Germany.
Aspenström P; the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Somlyo AV; the Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, and.
Dvorsky R; From the Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf, Germany, radovan.dvorsky@uni-duesseldorf.de.
Ahmadian MR; From the Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, 40225 Düsseldorf, Germany, reza.ahmadian@uni-duesseldorf.de.

J Biol Chem ; 291(39): 20353-71, 2016 09 23.

Article em En | MEDLINE | ID: mdl-27481945

Assuntos

Proteínas Ativadoras de GTPase/química; Proteínas rho de Ligação ao GTP/química; Proteínas Ativadoras de GTPase/genética; Proteínas Ativadoras de GTPase/metabolismo; Humanos; Domínios Proteicos; Relação Estrutura-Atividade; Proteínas rho de Ligação ao GTP/genética; Proteínas rho de Ligação ao GTP/metabolismo

Palavras-chave

GTPase; GTPase-activating protein (GAP); RAC (RAC GTPase); Ras homolog gene family, member A (RHOA); arginine finger; crystal structure; deleted in liver cancer 1 (DLC1); protein-protein interaction; signal transduction; substrate specificity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas rho de Ligação ao GTP / Proteínas Ativadoras de GTPase Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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