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A Fibroblast Growth Factor 21-Pregnane X Receptor Pathway Downregulates Hepatic CYP3A4 in Nonalcoholic Fatty Liver Disease.
Woolsey, Sarah J; Beaton, Melanie D; Mansell, Sara E; Leon-Ponte, Matilde; Yu, Janice; Pin, Christopher L; Adams, Paul C; Kim, Richard B; Tirona, Rommel G.
Afiliação
  • Woolsey SJ; Department of Physiology and Pharmacology (S.J.W., J.Y., C.L.P., R.B.K., R.G.T), Division of Gastroenterology, Department of Medicine (M.D.B., P.C.A.), Division of Clinical Pharmacology, Department of Medicine (S.J.W., S.E.M., M.L.-P., J.Y., R.B.K., R.G.T.), Department of Paediatrics (C.L.P.), and D
  • Beaton MD; Department of Physiology and Pharmacology (S.J.W., J.Y., C.L.P., R.B.K., R.G.T), Division of Gastroenterology, Department of Medicine (M.D.B., P.C.A.), Division of Clinical Pharmacology, Department of Medicine (S.J.W., S.E.M., M.L.-P., J.Y., R.B.K., R.G.T.), Department of Paediatrics (C.L.P.), and D
  • Mansell SE; Department of Physiology and Pharmacology (S.J.W., J.Y., C.L.P., R.B.K., R.G.T), Division of Gastroenterology, Department of Medicine (M.D.B., P.C.A.), Division of Clinical Pharmacology, Department of Medicine (S.J.W., S.E.M., M.L.-P., J.Y., R.B.K., R.G.T.), Department of Paediatrics (C.L.P.), and D
  • Leon-Ponte M; Department of Physiology and Pharmacology (S.J.W., J.Y., C.L.P., R.B.K., R.G.T), Division of Gastroenterology, Department of Medicine (M.D.B., P.C.A.), Division of Clinical Pharmacology, Department of Medicine (S.J.W., S.E.M., M.L.-P., J.Y., R.B.K., R.G.T.), Department of Paediatrics (C.L.P.), and D
  • Yu J; Department of Physiology and Pharmacology (S.J.W., J.Y., C.L.P., R.B.K., R.G.T), Division of Gastroenterology, Department of Medicine (M.D.B., P.C.A.), Division of Clinical Pharmacology, Department of Medicine (S.J.W., S.E.M., M.L.-P., J.Y., R.B.K., R.G.T.), Department of Paediatrics (C.L.P.), and D
  • Pin CL; Department of Physiology and Pharmacology (S.J.W., J.Y., C.L.P., R.B.K., R.G.T), Division of Gastroenterology, Department of Medicine (M.D.B., P.C.A.), Division of Clinical Pharmacology, Department of Medicine (S.J.W., S.E.M., M.L.-P., J.Y., R.B.K., R.G.T.), Department of Paediatrics (C.L.P.), and D
  • Adams PC; Department of Physiology and Pharmacology (S.J.W., J.Y., C.L.P., R.B.K., R.G.T), Division of Gastroenterology, Department of Medicine (M.D.B., P.C.A.), Division of Clinical Pharmacology, Department of Medicine (S.J.W., S.E.M., M.L.-P., J.Y., R.B.K., R.G.T.), Department of Paediatrics (C.L.P.), and D
  • Kim RB; Department of Physiology and Pharmacology (S.J.W., J.Y., C.L.P., R.B.K., R.G.T), Division of Gastroenterology, Department of Medicine (M.D.B., P.C.A.), Division of Clinical Pharmacology, Department of Medicine (S.J.W., S.E.M., M.L.-P., J.Y., R.B.K., R.G.T.), Department of Paediatrics (C.L.P.), and D
  • Tirona RG; Department of Physiology and Pharmacology (S.J.W., J.Y., C.L.P., R.B.K., R.G.T), Division of Gastroenterology, Department of Medicine (M.D.B., P.C.A.), Division of Clinical Pharmacology, Department of Medicine (S.J.W., S.E.M., M.L.-P., J.Y., R.B.K., R.G.T.), Department of Paediatrics (C.L.P.), and D
Mol Pharmacol ; 90(4): 437-46, 2016 10.
Article em En | MEDLINE | ID: mdl-27482056
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Receptores de Esteroides / Regulação para Baixo / Citocromo P-450 CYP3A / Fatores de Crescimento de Fibroblastos / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Receptores de Esteroides / Regulação para Baixo / Citocromo P-450 CYP3A / Fatores de Crescimento de Fibroblastos / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article