Synthesis of Isoindolinones by Pd-Catalyzed Coupling between N-Methoxybenzamide and Styrene Derivatives.
J Org Chem
; 81(17): 7931-7938, 2016 Sep 02.
Article
em En
| MEDLINE
| ID: mdl-27494701
ABSTRACT
An atom-economical protocol for a tandem process involving Fujiwara-Moritani-aza-Wacker reactions has been developed for the Pd-catalyzed coupling between N-methoxy benzamide and styrene derivatives. The generality of the methodology was demonstrated by the synthesis of a library of 25 3-benzylidene isoindolinones in moderate to good yields. A further 40 3-benzyl derivatives were obtained by telescoping the process with a catalytic hydrogenation reaction.
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MEDLINE
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En
Ano de publicação:
2016
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Article