Simple procedures for preparing putative toxic metabolites of pyrrolizidine alkaloids.
Toxicon
; 27(5): 561-7, 1989.
Article
em En
| MEDLINE
| ID: mdl-2749755
ABSTRACT
New procedures are described for converting unsaturated pyrrolizidine alkaloids to chemically reactive pyrrolic esters (dehydro-alkaloids), which are probable primary toxic metabolites formed from these alkaloids in vivo. Preparations of dehydro-necines, including dehydroretronecine (DHR) are also described. Dehydrocrotanecine, and four new dehydro-alkaloids, are described for the first time. The methods give superior yields to earlier procedures, do not require a high degree of chemical expertise, and are particularly suitable for making small amounts of compounds for toxicological experiments.
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Base de dados:
MEDLINE
Assunto principal:
Alcaloides de Pirrolizidina
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article