Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation.

Corbet, Cyril; Pinto, Adán; Martherus, Ruben; Santiago de Jesus, João Pedro; Polet, Florence; Feron, Olivier

Corbet, Cyril; Pinto, Adán; Martherus, Ruben; Santiago de Jesus, João Pedro; Polet, Florence; Feron, Olivier.

Afiliação

Corbet C; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 53 Avenue Mounier B1.53.09, 1200 Brussels, Belgium.
Pinto A; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 53 Avenue Mounier B1.53.09, 1200 Brussels, Belgium.
Martherus R; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 53 Avenue Mounier B1.53.09, 1200 Brussels, Belgium.
Santiago de Jesus JP; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 53 Avenue Mounier B1.53.09, 1200 Brussels, Belgium.
Polet F; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 53 Avenue Mounier B1.53.09, 1200 Brussels, Belgium.
Feron O; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, 53 Avenue Mounier B1.53.09, 1200 Brussels, Belgium. Electronic address: olivier.feron@uclouvain.be.

Cell Metab ; 24(2): 311-23, 2016 08 09.

Article em En | MEDLINE | ID: mdl-27508876

Assuntos

Acidose/metabolismo; Reprogramação Celular; Ácidos Graxos/metabolismo; Histonas/metabolismo; Mitocôndrias/metabolismo; Neoplasias/metabolismo; Acetilcoenzima A/metabolismo; Acetilação; Animais; Linhagem Celular Tumoral; Proliferação de Células; Respiração Celular; Complexo I de Transporte de Elétrons/metabolismo; Feminino; Glutamina/metabolismo; Humanos; Concentração de Íons de Hidrogênio; Redes e Vias Metabólicas; Camundongos Nus; Modelos Biológicos; Neoplasias/patologia; Oxirredução; Espécies Reativas de Oxigênio/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acidose / Histonas / Reprogramação Celular / Ácidos Graxos / Mitocôndrias / Neoplasias Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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