Blood transfusion in preterm infants improves intestinal tissue oxygenation without alteration in blood flow.
Vox Sang
; 111(4): 399-408, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27509230
ABSTRACT
BACKGROUND AND OBJECTIVE:
The objective of the study was to investigate the splanchnic blood flow velocity and oximetry response to blood transfusion in preterm infants according to postnatal age. MATERIALS ANDMETHODS:
Preterm infants receiving blood transfusion were recruited to three groups 1-7 (group 1; n = 20), 8-28 (group 2; n = 21) and ≥29 days of life (group 3; n = 18). Superior mesenteric artery (SMA) peak systolic (PSV) and diastolic velocities were measured 30-60 min pre- and post-transfusion using Doppler ultrasound scan. Splanchnic tissue haemoglobin index (sTHI), tissue oxygenation index (sTOI) and fractional tissue oxygen extraction (sFTOE) were measured from 15-20 min before to post-transfusion using near-infrared spectroscopy.RESULTS:
The mean pretransfusion Hb in group 1, 2 and 3 was 11, 10 and 9 g/dl, respectively. The mean (SD) pretransfusion SMA PSV in group 1, 2 and 3 was 0·63 (0·32), 0·81 (0·33) and 0·97 (0·40) m/s, respectively, and this did not change significantly following transfusion. The mean (SD) pretransfusion sTOI in group 1, 2 and 3 was 36·7 (19·3), 44·6 (10·4) and 41·3 (10·4)%, respectively. The sTHI and sTOI increased (P < 0·01), and sFTOE decreased (P < 0·01) following transfusion in all groups. On multivariate analysis, changes in SMA PSV and sTOI following blood transfusion were not associated with PDA, feeding, pretransfusion Hb and mean blood pressure.CONCLUSION:
Pretransfusion baseline splanchnic tissue oximetry and blood flow velocity varied with postnatal age. Blood transfusion improved intestinal tissue oxygenation without altering mesenteric blood flow velocity irrespective of postnatal ages.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Circulação Esplâncnica
Limite:
Female
/
Humans
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Infant
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Male
/
Newborn
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article