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Combined DTI-fMRI Analysis for a Quantitative Assessment of Connections Between WM Bundles and Their Peripheral Cortical Fields in Verbal Fluency.
Scaccianoce, Elisa; Laganà, Maria Marcella; Baglio, Francesca; Preti, Maria Giulia; Bergsland, Niels; Cecconi, Pietro; Clerici, Mario; Baselli, Giuseppe; Papadimitriou, George; Makris, Nikos.
Afiliação
  • Scaccianoce E; Magnetic Resonance Laboratory, Fondazione Don Carlo Gnocchi ONLUS, IRCCS S. Maria Nascente, Via Capecelatro 66, 20148, Milan, Italy.
  • Laganà MM; Department of Electronics, Information and Bioengineering, Politecnico di Milano, 20133, Milan, Italy.
  • Baglio F; Magnetic Resonance Laboratory, Fondazione Don Carlo Gnocchi ONLUS, IRCCS S. Maria Nascente, Via Capecelatro 66, 20148, Milan, Italy. mlagana@dongnocchi.it.
  • Preti MG; Magnetic Resonance Laboratory, Fondazione Don Carlo Gnocchi ONLUS, IRCCS S. Maria Nascente, Via Capecelatro 66, 20148, Milan, Italy.
  • Bergsland N; Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, CH-1015, Switzerland.
  • Cecconi P; Department of Radiology and Medical Informatics, University of Geneva, Geneva, CH-1211, Switzerland.
  • Clerici M; Magnetic Resonance Laboratory, Fondazione Don Carlo Gnocchi ONLUS, IRCCS S. Maria Nascente, Via Capecelatro 66, 20148, Milan, Italy.
  • Baselli G; Department of Electronics, Information and Bioengineering, Politecnico di Milano, 20133, Milan, Italy.
  • Papadimitriou G; Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
  • Makris N; Magnetic Resonance Laboratory, Fondazione Don Carlo Gnocchi ONLUS, IRCCS S. Maria Nascente, Via Capecelatro 66, 20148, Milan, Italy.
Brain Topogr ; 29(6): 814-823, 2016 11.
Article em En | MEDLINE | ID: mdl-27509899
Diffusion tensor imaging (DTI) tractography and functional magnetic resonance imaging (fMRI) are powerful techniques to elucidate the anatomical and functional aspects of brain connectivity. However, integrating these approaches to describe the precise link between structure and function within specific brain circuits remains challenging. In this study, a novel DTI-fMRI integration method is proposed, to provide the topographical characterization and the volumetric assessment of the functional and anatomical connections within the language circuit. In a group of 21 healthy elderly subjects (mean age 68.5 ± 5.8 years), the volume of connection between the cortical activity elicited by a verbal fluency task and the cortico-cortical fiber tracts associated with this function are mapped and quantified. An application of the method to a case study in neuro-rehabilitation context is also presented. Integrating structural and functional data within the same framework, this approach provides an overall view of white and gray matter when studying specific brain circuits.
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Base de dados: MEDLINE Assunto principal: Fala / Córtex Cerebral / Substância Cinzenta / Substância Branca / Idioma Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Fala / Córtex Cerebral / Substância Cinzenta / Substância Branca / Idioma Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article