2-(4-{2-[(phenylthio)acetyl]carbonohydrazonoyl}phenoxy)acetamide as a new lead compound for management of allergic rhinitis.

Kim, Hee-Yun; Nam, Sun-Young; Jang, Jae-Bum; Choi, Youngjin; Kang, In-Cheol; Kim, Hyung-Min; Jeong, Hyun-Ja

Kim, Hee-Yun; Nam, Sun-Young; Jang, Jae-Bum; Choi, Youngjin; Kang, In-Cheol; Kim, Hyung-Min; Jeong, Hyun-Ja.

Afiliação

Kim HY; Department of Pharmacology, Graduate School, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.
Nam SY; Department of Pharmacology, Graduate School, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.
Jang JB; Department of Pharmaceutical Engineering and Inflammatory Disease Research Center, Hoseo University, Asan, Chungnam, 31499, Republic of Korea.
Choi Y; Department of Food Technology and Inflammatory Disease Research Center, Hoseo University, 20 Hoseo-ro, 79 Beon-gil, Baebang-eup, Asan, Chungnam, 31499, Republic of Korea.
Kang IC; Biochip Research Center and Inflammatory Disease Research Center, Hoseo University, Asan, Chungnam, 31499, Republic of Korea.
Kim HM; Department of Pharmacology, Graduate School, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea. hmkim@khu.ac.kr.
Jeong HJ; Department of Food Technology and Inflammatory Disease Research Center, Hoseo University, 20 Hoseo-ro, 79 Beon-gil, Baebang-eup, Asan, Chungnam, 31499, Republic of Korea. hjjeong@hoseo.edu.

Inflamm Res ; 65(12): 963-973, 2016 Dec.

Article em En | MEDLINE | ID: mdl-27516212

Assuntos

Acetamidas/uso terapêutico; Antialérgicos/uso terapêutico; Hidrazonas/uso terapêutico; Rinite Alérgica/tratamento farmacológico; Acetamidas/farmacologia; Alérgenos; Animais; Antialérgicos/farmacologia; Caspase 1/metabolismo; Linhagem Celular; Sobrevivência Celular/efeitos dos fármacos; Ciclo-Oxigenase 2/metabolismo; Citocinas/sangue; Citocinas/metabolismo; Feminino; Histamina/sangue; Humanos; Hidrazonas/farmacologia; Imunoglobulina E/sangue; Camundongos Endogâmicos BALB C; Simulação de Acoplamento Molecular; Mucosa Nasal/efeitos dos fármacos; Mucosa Nasal/metabolismo; Ovalbumina; Rinite Alérgica/sangue; Rinite Alérgica/metabolismo; Baço/efeitos dos fármacos; Baço/metabolismo

Palavras-chave

2-(4-{2-[(phenylthio)acetyl]carbonohydrazonoyl}phenoxy)acetamide; Allergic rhinitis; Caspase-1; Molecular docking simulation; TSLP

Buscar no Google

Imprimir

XML

PubMed Links

Base de dados: MEDLINE Assunto principal: Antialérgicos / Rinite Alérgica / Hidrazonas / Acetamidas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Buscar no Google

Imprimir

XML

PubMed Links