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Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments.
Haftchenary, Sina; Nelson, Shawn D; Furst, Laura; Dandapani, Sivaraman; Ferrara, Steven J; Boskovic, Zarko V; Figueroa Lazú, Samuel; Guerrero, Adrian M; Serrano, Juan C; Crews, DeMarcus K; Brackeen, Cristina; Mowat, Jeffrey; Brumby, Thomas; Bauser, Marcus; Schreiber, Stuart L; Phillips, Andrew J.
Afiliação
  • Haftchenary S; Center for the Science of Therapeutics, Broad Institute , 415 Main Street, Cambridge, Massachusetts 02142, United States.
  • Nelson SD; Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
  • Furst L; Center for the Science of Therapeutics, Broad Institute , 415 Main Street, Cambridge, Massachusetts 02142, United States.
  • Dandapani S; Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
  • Ferrara SJ; Center for the Science of Therapeutics, Broad Institute , 415 Main Street, Cambridge, Massachusetts 02142, United States.
  • Boskovic ZV; Center for the Science of Therapeutics, Broad Institute , 415 Main Street, Cambridge, Massachusetts 02142, United States.
  • Figueroa Lazú S; Center for the Science of Therapeutics, Broad Institute , 415 Main Street, Cambridge, Massachusetts 02142, United States.
  • Guerrero AM; Center for the Science of Therapeutics, Broad Institute , 415 Main Street, Cambridge, Massachusetts 02142, United States.
  • Serrano JC; Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
  • Crews DK; Center for the Science of Therapeutics, Broad Institute , 415 Main Street, Cambridge, Massachusetts 02142, United States.
  • Brackeen C; Center for the Science of Therapeutics, Broad Institute , 415 Main Street, Cambridge, Massachusetts 02142, United States.
  • Mowat J; Center for the Science of Therapeutics, Broad Institute , 415 Main Street, Cambridge, Massachusetts 02142, United States.
  • Brumby T; Center for the Science of Therapeutics, Broad Institute , 415 Main Street, Cambridge, Massachusetts 02142, United States.
  • Bauser M; Center for the Science of Therapeutics, Broad Institute , 415 Main Street, Cambridge, Massachusetts 02142, United States.
  • Schreiber SL; Bayer Pharma AG , Drug Discovery, Müllerstraße, 178, 13353 Berlin, Germany.
  • Phillips AJ; Bayer Pharma AG , Drug Discovery, Müllerstraße, 178, 13353 Berlin, Germany.
ACS Comb Sci ; 18(9): 569-74, 2016 09 12.
Article em En | MEDLINE | ID: mdl-27518324
ABSTRACT
Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1-5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and sultams. These fragments have molecular weights ranging from 100 to 255 Da and are soluble in water (0.085 to >15 mM).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Amino Álcoois Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Amino Álcoois Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article