Osteonecrosis detected by whole body magnetic resonance in patients with Hodgkin Lymphoma treated by BEACOPP.
Eur Radiol
; 27(5): 2129-2136, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-27519911
ABSTRACT
OBJECTIVES:
The purpose of our retrospective review of prospectively acquired Whole Body Magnetic Resonance (WB-MRI) scans was to assess the incidence of osteonecrosis in patients who received different chemotherapies.METHODS:
We evaluated the WB-MRI scans performed on 42 patients with Hodgkin Lymphoma treated by three chemotherapy regimens (6ABVD, 2ABVD + 4BEACOPP, 2ABVD + 8BEACOPP), excluding patients with the main risk factors for osteonecrosis.RESULTS:
Six out of seven patients (86 %) who received eight BEACOPP and one out of five patients (20 %) treated by four BEACOPP presented osteonecrosis, with a statistically significant difference of frequency between the two groups of patients (p < 0.05); no injury has been reported in patients treated by only ABVD. Among a total of 48 osteonecrotic lesions observed, 48 % were detected in the knee; multifocal osteonecrosis were detected in six out of seven patients (86 %).CONCLUSIONS:
The development of osteonecrosis is strictly related to the chemotherapy protocol adopted and the number of cycles received, with a strong correlation between the dose of corticosteroids included in the BEACOPP scheme and this complication. WB-MRI can be considered as a helpful tool that allows detecting earlier osteonecrotic lesions in patients treated with corticosteroids. KEY POINTS ⢠Osteonecrosis is a possible complication of patients with Lymphoma treated by chemotherapy. ⢠Osteonecrosis is related to the corticosteroids included within the BEACOPP protocol. ⢠WB-MRI allows detecting osteonecrotic lesions in patients treated with corticosteroids.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Osteonecrose
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Doença de Hodgkin
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Protocolos de Quimioterapia Combinada Antineoplásica
Tipo de estudo:
Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article