(E)-9-oxooctadec-10-en-12-ynoic acid from Ixora brachiata Roxb. increases glucose uptake in L6 myotubes by activating the PI3K pathway.

Thakkar, Chandni S; Kshirsagar, Rajendra R; Naik, Vinayak R; Ghosh, Asit Ranjan; Vijayakumar, V; Saklani, Arvind; Kulkarni-Almeida, Asha A

Thakkar, Chandni S; Kshirsagar, Rajendra R; Naik, Vinayak R; Ghosh, Asit Ranjan; Vijayakumar, V; Saklani, Arvind; Kulkarni-Almeida, Asha A.

Afiliação

Thakkar CS; Screening - Metabolic Disorders Translational Unit, Piramal Enterprises Limited, 1A - Nirlon Complex, Off Western Express Highway, Goregaon (East), Mumbai 400 063, Maharashtra, India.
Kshirsagar RR; Discovery Analytical Sciences Department, Piramal Enterprises Limited, 1A - Nirlon Complex, Off Western Express Highway, Goregaon (East), Mumbai 400 063, Maharashtra, India.
Naik VR; Natural Products, Piramal Enterprises Limited, 1A - Nirlon Complex, Off Western Express Highway, Goregaon (East), Mumbai 400 063, Maharashtra, India.
Ghosh AR; Centre for Infectious Diseases & Control, School of BioSciences and Technology, VIT University, Vellore 632014, India.
Vijayakumar V; Centre for Organic and Medicinal Chemistry, VIT University, Vellore 632014, India.
Saklani A; Natural Products, Piramal Enterprises Limited, 1A - Nirlon Complex, Off Western Express Highway, Goregaon (East), Mumbai 400 063, Maharashtra, India.
Kulkarni-Almeida AA; Screening - Metabolic Disorders Translational Unit, Piramal Enterprises Limited, 1A - Nirlon Complex, Off Western Express Highway, Goregaon (East), Mumbai 400 063, Maharashtra, India. Electronic address: asha.almeida@gmail.com.

Fitoterapia ; 114: 26-33, 2016 Oct.

Article em En | MEDLINE | ID: mdl-27521895

Assuntos

Di-Inos/farmacologia; Ácidos Graxos Insaturados/farmacologia; Glucose/metabolismo; Fibras Musculares Esqueléticas/efeitos dos fármacos; Extratos Vegetais/farmacologia; Rubiaceae/química; Transdução de Sinais; Animais; Células Cultivadas; Di-Inos/isolamento & purificação; Ácidos Graxos Insaturados/isolamento & purificação; Proteínas Ativadoras de GTPase/metabolismo; Transportador de Glucose Tipo 4/metabolismo; Insulina/farmacologia; Proteínas Substratos do Receptor de Insulina/metabolismo; Fibras Musculares Esqueléticas/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Fosforilação; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ratos

Palavras-chave

(E)-9-oxooctadec-10-en-12-ynoic acid; Akt; GLUT4; Ixora brachiata; L6 myotubes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Transdução de Sinais / Fibras Musculares Esqueléticas / Rubiaceae / Di-Inos / Ácidos Graxos Insaturados / Glucose Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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