Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions.
Nat Nanotechnol
; 11(11): 941-947, 2016 11.
Article
em En
| MEDLINE
| ID: mdl-27525475
ABSTRACT
Oxygen-depleted hypoxic regions in the tumour are generally resistant to therapies. Although nanocarriers have been used to deliver drugs, the targeting ratios have been very low. Here, we show that the magneto-aerotactic migration behaviour of magnetotactic bacteria, Magnetococcus marinus strain MC-1 (ref. 4), can be used to transport drug-loaded nanoliposomes into hypoxic regions of the tumour. In their natural environment, MC-1 cells, each containing a chain of magnetic iron-oxide nanocrystals, tend to swim along local magnetic field lines and towards low oxygen concentrations based on a two-state aerotactic sensing system. We show that when MC-1 cells bearing covalently bound drug-containing nanoliposomes were injected near the tumour in severe combined immunodeficient beige mice and magnetically guided, up to 55% of MC-1 cells penetrated into hypoxic regions of HCT116 colorectal xenografts. Approximately 70 drug-loaded nanoliposomes were attached to each MC-1 cell. Our results suggest that harnessing swarms of microorganisms exhibiting magneto-aerotactic behaviour can significantly improve the therapeutic index of various nanocarriers in tumour hypoxic regions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Férricos
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Neoplasias Colorretais
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Sistemas de Liberação de Medicamentos
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Alphaproteobacteria
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Nanopartículas
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Campos Magnéticos
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Neoplasias Experimentais
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article