Stem Cell Therapy for the Heart: Blind Alley or Magic Bullet?
J Cardiovasc Transl Res
; 9(5-6): 405-418, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27542008
ABSTRACT
When stressed by ageing or disease, the adult human heart is unable to regenerate, leading to scarring and hypertrophy and eventually heart failure. As a result, stem cell therapy has been proposed as an ultimate therapeutic strategy, as stem cells could limit adverse remodelling and give rise to new cardiomyocytes and vasculature. Unfortunately, the results from clinical trials to date have been largely disappointing. In this review, we discuss the current status of the field and describe various limitations and how future work may attempt to resolve these to make way to successful clinical translation.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regeneração
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Miócitos Cardíacos
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Transplante de Células-Tronco
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Medicina Regenerativa
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Cardiopatias
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article