Influence of wound fluid on chemotherapy sensitivity in primary breast cancer cells.
Oncotarget
; 7(40): 65034-65041, 2016 10 04.
Article
em En
| MEDLINE
| ID: mdl-27542254
ABSTRACT
OBJECTIVE:
To investigate the effect of WF on chemotherapy sensitivities of primary breast cancer cells from breast cancer patients by using CD-DST.RESULTS:
In general, the WF-treated cells showed remarkable increase in survival rates as compared to the control cells cultured without WF among different anticancer drug subgroups. This trend was generally observed in all the tumor cells from the premenopausal, postmenopausal, T2, N0, N1, luminal B, and TN patients.METHODS:
The sensitivities of WF-treated primary breast cancer cells, from 21 patients who underwent a radical resection for breast cancer from September 2014 to July 2015, to anticancer drugs EPI, CDDP, DOC, VNR, 5-FU+LV, and PAC, were obtained using CD-DST. The survival rates of the breast cancer cells were recorded and used to gauge the chemotherapeutic effect.CONCLUSIONS:
Surgery-induced WF promotes the drug resistance of primary breast cancer cells to chemotherapy, suggesting that surgery may have adverse effects on breast cancer patients. More studies are needed to investigate the key factors in WF that enhance the susceptibility to chemotherapy drugs.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Deiscência da Ferida Operatória
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Ferimentos e Lesões
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Líquidos Corporais
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Neoplasias da Mama
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Ensaios de Seleção de Medicamentos Antitumorais
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Mastectomia
/
Antineoplásicos
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article