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Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument.
Furet, Pascal; Masuya, Keiichi; Kallen, Joerg; Stachyra-Valat, Thérèse; Ruetz, Stephan; Guagnano, Vito; Holzer, Philipp; Mah, Robert; Stutz, Stefan; Vaupel, Andrea; Chène, Patrick; Jeay, Sébastien; Schlapbach, Achim.
Afiliação
  • Furet P; Novartis Institutes for BioMedical Research, WKL-136.P.12, CH-4002 Basel, Switzerland. Electronic address: pascal.furet@novartis.com.
  • Masuya K; Novartis Institutes for BioMedical Research, WKL-136.P.12, CH-4002 Basel, Switzerland.
  • Kallen J; Novartis Institutes for BioMedical Research, WKL-136.P.12, CH-4002 Basel, Switzerland.
  • Stachyra-Valat T; Novartis Institutes for BioMedical Research, WKL-136.P.12, CH-4002 Basel, Switzerland.
  • Ruetz S; Novartis Institutes for BioMedical Research, WKL-136.P.12, CH-4002 Basel, Switzerland.
  • Guagnano V; Novartis Institutes for BioMedical Research, WKL-136.P.12, CH-4002 Basel, Switzerland.
  • Holzer P; Novartis Institutes for BioMedical Research, WKL-136.P.12, CH-4002 Basel, Switzerland.
  • Mah R; Novartis Institutes for BioMedical Research, WKL-136.P.12, CH-4002 Basel, Switzerland.
  • Stutz S; Novartis Institutes for BioMedical Research, WKL-136.P.12, CH-4002 Basel, Switzerland.
  • Vaupel A; Novartis Institutes for BioMedical Research, WKL-136.P.12, CH-4002 Basel, Switzerland.
  • Chène P; Novartis Institutes for BioMedical Research, WKL-136.P.12, CH-4002 Basel, Switzerland.
  • Jeay S; Novartis Institutes for BioMedical Research, WKL-136.P.12, CH-4002 Basel, Switzerland.
  • Schlapbach A; Novartis Institutes for BioMedical Research, WKL-136.P.12, CH-4002 Basel, Switzerland.
Bioorg Med Chem Lett ; 26(19): 4837-4841, 2016 10 01.
Article em En | MEDLINE | ID: mdl-27542305
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas c-mdm2 / Descoberta de Drogas Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas c-mdm2 / Descoberta de Drogas Idioma: En Ano de publicação: 2016 Tipo de documento: Article