Systemic Therapy for Advanced Soft Tissue Sarcoma.
Surg Clin North Am
; 96(5): 1141-56, 2016 Oct.
Article
em En
| MEDLINE
| ID: mdl-27542647
ABSTRACT
Soft tissue sarcomas are rare tumors that present with distant metastasis in up to 10% of patients. Survival has improved significantly because of advancements in histologic classification and improved management approaches. Older agents such as doxorubicin, ifosfamide, gemcitabine, and paclitaxel continue to demonstrate objective response rates from 18% to 25%. Newer agents such as trabectedin, eribulin, aldoxorubicin, and olaratumab have demonstrated improvements in progression-free survival, overall survival, or toxicity profiles. Future studies on treatment of advanced soft tissue sarcoma will continue to concentrate on reducing toxicity, personalization of therapy, and targeting novel pathways.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sarcoma
/
Gerenciamento Clínico
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article