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Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin.
Li, Zhong-Rui; Li, Jie; Gu, Jin-Ping; Lai, Jennifer Y H; Duggan, Brendan M; Zhang, Wei-Peng; Li, Zhi-Long; Li, Yong-Xin; Tong, Rong-Biao; Xu, Ying; Lin, Dong-Hai; Moore, Bradley S; Qian, Pei-Yuan.
Afiliação
  • Li ZR; Division of Life Science and Environmental Science Programs, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
  • Li J; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, USA.
  • Gu JP; High-field NMR Research Center, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.
  • Lai JY; Division of Life Science and Environmental Science Programs, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
  • Duggan BM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.
  • Zhang WP; Division of Life Science and Environmental Science Programs, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
  • Li ZL; Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
  • Li YX; Division of Life Science and Environmental Science Programs, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
  • Tong RB; Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
  • Xu Y; Shenzhen Key Laboratory of Marine Bioresource &Ecoenvironmental Science, Shenzhen Engineering Laboratory for Marine Algal Biotechnology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, China.
  • Lin DH; High-field NMR Research Center, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.
  • Moore BS; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, USA.
  • Qian PY; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA.
Nat Chem Biol ; 12(10): 773-5, 2016 10.
Article em En | MEDLINE | ID: mdl-27547923
ABSTRACT
Colibactin is an as-yet-uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886, which uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block into its unprecedented macrocyclic structure. This work provides new insights into the biosynthetic logic and mode of action of this colorectal-cancer-linked microbial chemical.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Policetídeos / Malonatos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Policetídeos / Malonatos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article