Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin.
Nat Chem Biol
; 12(10): 773-5, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27547923
ABSTRACT
Colibactin is an as-yet-uncharacterized genotoxic secondary metabolite produced by human gut bacteria. Here we report the biosynthetic discovery of two new precolibactin molecules from Escherichia coli, including precolibactin-886, which uniquely incorporates the highly sought genotoxicity-associated aminomalonate building block into its unprecedented macrocyclic structure. This work provides new insights into the biosynthetic logic and mode of action of this colorectal-cancer-linked microbial chemical.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Policetídeos
/
Malonatos
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article