Investigation of suitable starting doses of narrowband UVB in Asian vitiligo patients: a pilot study.
J Eur Acad Dermatol Venereol
; 31(5): 894-897, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-27549434
ABSTRACT
BACKGROUND:
Phototherapy is the preferred treatment modality for active and generalized vitiligo. One of the widely accepted consensus on starting dose of phototherapy is using a uniform dose of 280 mJ/cm2 regardless of patients' Fitzpatrick skin phototype (SPT). However, in many clinical experiences with Asian vitiligo patients, the protocol seems suboptimal.OBJECTIVE:
To gather more evidence on establishing a higher starting dosage for Asian vitiligo patients undergoing phototherapy.METHODS:
We enrolled generalized vitiligo patients with lesions sized adequate enough for phototest. Minimal erythema dose (MED) of vitiligo lesion and non-lesion was measured along with melanin index (MI).RESULTS:
Relatively, a wide range of MED and MI was observed even among patients with similar SPT. The range of MED for lesional skin was 300-700 mJ/cm2 and the MED for non-lesion was 500-800 mJ/cm2 . Correlation was noted between lesional MED and non-lesional MI (Spearman correlation, ρ = 0.664 [P < 0.036]) and mean lesional MED was approximately 65% of mean non-lesional MED.CONCLUSION:
Results from phototest and tolerability of patients to doses higher than 280 mJ/cm2 may indicate that higher starting doses might be appropriate for Asian vitiligo patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fototerapia
/
Raios Ultravioleta
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Vitiligo
Tipo de estudo:
Guideline
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article