Management of Oropharyngeal Cancer in the HPV Era.
Cancer Control
; 23(3): 197-207, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-27556659
ABSTRACT
BACKGROUND:
Historically, oropharyngeal cancer (OPC) has been attributed to risk factors such as smoking and alcohol use. The increased incidence of OPC has been driven by human papillomavirus (HPV) infection.METHODS:
A search of the literature involving HPV infection and OPC was performed, along with a search of ongoing clinical trials regarding HPV-positive OPC.RESULTS:
This review summarizes the differences in epidemiology and prognosis of HPV-positive OPC compared with non-HPV-related OPC. It will also discuss use of de-escalating treatment to minimize toxicity while maintaining excellent outcomes. Disease management is also addressed, including prevention and follow-up recommendations for this cohort of patients.CONCLUSIONS:
HPV-positive OPC is a distinct disease, and efforts should be made to personalize its management. Preventive measures and vaccinations, along with de-escalation of treatment, may help optimize outcomes in this population.
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Base de dados:
MEDLINE
Assunto principal:
Papillomaviridae
/
Neoplasias Orofaríngeas
/
Infecções por Papillomavirus
Tipo de estudo:
Etiology_studies
/
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article