Nanomedicine Meets microRNA: Current Advances in RNA-Based Nanotherapies for Atherosclerosis.
Arterioscler Thromb Vasc Biol
; 36(9): e73-9, 2016 09.
Article
em En
| MEDLINE
| ID: mdl-27559146
ABSTRACT
Cardiovascular disease (CVD) accounts for almost half of all deaths worldwide and has now surpassed infectious disease as the leading cause of death and disability in developing countries. At present, therapies such as low-density lipoprotein-lowering statins and antihypertensive drugs have begun to bend the morality curve for coronary artery disease (CAD); yet, as we come to appreciate the more complex pathophysiological processes in the vessel wall, there is an opportunity to fine-tune therapies to more directly target mechanisms that drive CAD. MicroRNAs (miRNAs) have been identified that control vascular cell homeostasis,(1-3) lipoprotein metabolism,(4-9) and inflammatory cell function.(10) Despite the importance of these miRNAs in driving atherosclerosis and vascular dysfunction, therapeutic modulation of miRNAs in a cell- and context-specific manner has been a challenge. In this review, we summarize the emergence of miRNA-based therapies as an approach to treat CAD by specifically targeting the pathways leading to the disease. We focus on the latest development of nanoparticles (NPs) as a means to specifically target the vessel wall and what the future of these nanomedicines may hold for the treatment of CAD.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
MicroRNAs
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Interferência de RNA
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Aterosclerose
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Nanomedicina
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Nanopartículas
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Terapêutica com RNAi
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
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Sysrev_observational_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article