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Concomitance of monosomal karyotype with at least 5 chromosomal abnormalities is associated with dismal treatment outcome of AML patients with complex karyotype - retrospective analysis of Polish Adult Leukemia Group (PALG).
Wierzbowska, Agnieszka; Wawrzyniak, Ewa; Siemieniuk-Rys, Monika; Kotkowska, Aleksandra; Pluta, Agnieszka; Golos, Aleksandra; Robak, Tadeusz; Szarawarska, Marta; Jaskowiec, Anna; Duszenko, Ewa; Rybka, Justyna; Holojda, Jadwiga; Grosicki, Sebastian; Pienkowska-Grela, Barbara; Woroniecka, Renata; Ejduk, Anna; Watek, Marzena; Wach, Malgorzata; Mucha, Barbara; Skonieczka, Katarzyna; Czyzewska, Maria; Jachalska, Anna; Klonowska, Agnieszka; Iliszko, Mariola; Knopinska-Posluszny, Wanda; Jarmuz-Szymczak, Malgorzata; Przybylowicz-Chalecka, Anna; Gil, Lidia; Kopacz, Agnieszka; Holowiecki, Jerzy; Haus, Olga.
Afiliação
  • Wierzbowska A; a Department of Hematology , Medical University of Lodz , Lodz , Poland.
  • Wawrzyniak E; a Department of Hematology , Medical University of Lodz , Lodz , Poland.
  • Siemieniuk-Rys M; b Department of Hematology , Copernicus Memorial Hospital , Lodz , Poland.
  • Kotkowska A; b Department of Hematology , Copernicus Memorial Hospital , Lodz , Poland.
  • Pluta A; a Department of Hematology , Medical University of Lodz , Lodz , Poland.
  • Golos A; b Department of Hematology , Copernicus Memorial Hospital , Lodz , Poland.
  • Robak T; a Department of Hematology , Medical University of Lodz , Lodz , Poland.
  • Szarawarska M; c Department of Hematology , Blood Malignancies and Bone Marrow Transplantation, Medical University of Wroclaw , Wroclaw , Poland.
  • Jaskowiec A; c Department of Hematology , Blood Malignancies and Bone Marrow Transplantation, Medical University of Wroclaw , Wroclaw , Poland.
  • Duszenko E; c Department of Hematology , Blood Malignancies and Bone Marrow Transplantation, Medical University of Wroclaw , Wroclaw , Poland.
  • Rybka J; c Department of Hematology , Blood Malignancies and Bone Marrow Transplantation, Medical University of Wroclaw , Wroclaw , Poland.
  • Holojda J; d Department of Hematology , WSS , Legnica , Poland.
  • Grosicki S; e Department of Hematology , ZSM of Chorzow , Chorzow , Poland.
  • Pienkowska-Grela B; f Cancer Genetics Laboratory of Pathology Department , M Sklodowska-Curie Memorial Cancer Center and Institute , Warsaw , Poland.
  • Woroniecka R; f Cancer Genetics Laboratory of Pathology Department , M Sklodowska-Curie Memorial Cancer Center and Institute , Warsaw , Poland.
  • Ejduk A; g Department of Hematology , Institute of Hematology and Blood Transfusion , Warsaw , Poland.
  • Watek M; h Department of Hematology , Holycross Cancer Center , Kielce , Poland.
  • Wach M; i Department of Hematooncology and Bone Marrow Transplantation , Medical University of Lublin , Lublin , Poland.
  • Mucha B; j Department of Clinical Genetics , Collegium Medicum of Nicolaus Copernicus University , Bydgoszcz , Poland.
  • Skonieczka K; j Department of Clinical Genetics , Collegium Medicum of Nicolaus Copernicus University , Bydgoszcz , Poland.
  • Czyzewska M; k Department of Hematology , Nicolaus Copernicus Municipal Specialist Hospital , Torun , Poland.
  • Jachalska A; l Department of Hematology , Medical University of Bydgoszcz , Bydgoszcz , Poland.
  • Klonowska A; m Department of Biology and Genetics , Medical University of Gdansk , Gdansk , Poland.
  • Iliszko M; m Department of Biology and Genetics , Medical University of Gdansk , Gdansk , Poland.
  • Knopinska-Posluszny W; n Department of Hematology , SP ZOZ WMCO Oncology Center , Olsztyn , Poland.
  • Jarmuz-Szymczak M; o Institute of Human Genetics, PAN , Poznan , Poland.
  • Przybylowicz-Chalecka A; p Department of Hematology and Bone Marrow Transplantation , University of Medical Sciences , Poznan , Poland.
  • Gil L; p Department of Hematology and Bone Marrow Transplantation , University of Medical Sciences , Poznan , Poland.
  • Kopacz A; p Department of Hematology and Bone Marrow Transplantation , University of Medical Sciences , Poznan , Poland.
  • Holowiecki J; q Department of Hematology , Oncology Center, Municipal Hospital , Rzeszow , Poland.
  • Haus O; r Department of Bone Marrow Transplantation , M. Sklodowska-Curie Institute of Oncology , Gliwice , Poland.
Leuk Lymphoma ; 58(4): 889-897, 2017 04.
Article em En | MEDLINE | ID: mdl-27561449
ABSTRACT
Monosomal karyotype (MK) and complex karyotype (CK) are poor prognostic factors in acute myeloid leukemia (AML). A comprehensive analysis of cytogenetic and clinical factors influencing an outcome of AML-CK+ was performed. The impact of cladribine containing induction on treatment results was also evaluated. We analyzed 125 patients with AML-CK+ treated within PALG protocols. MK was found in 75 (60%) individuals. The overall complete remission (CR) rate of 66 intensively treated patients was 62% vs. 28% in CK+ MK- and CK+ MK+ group (p = .01). No difference in CR rate was observed between DA and DAC arms. The overall survival (OS) in intensively treated patients was negatively influenced by MK, karyotype complexity (≥5 abnormalities), and WBC >20 G/L in multivariate analysis. The addition of cladribine to DA regimen improved OS only in MK- but not in MK+ group. In conclusion, concomitance of MK with ≥5 chromosomal abnormalities is associated with dismal treatment outcome in AMK-CK+.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Aberrações Cromossômicas / Cariótipo / Monossomia Tipo de estudo: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Aberrações Cromossômicas / Cariótipo / Monossomia Tipo de estudo: Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2017 Tipo de documento: Article