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The interplay between cell signalling and the mevalonate pathway in cancer.
Mullen, Peter J; Yu, Rosemary; Longo, Joseph; Archer, Michael C; Penn, Linda Z.
Afiliação
  • Mullen PJ; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada M5G 1L7.
  • Yu R; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada M5G 1L7.
  • Longo J; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5G 1L7.
  • Archer MC; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada M5G 1L7.
  • Penn LZ; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5G 1L7.
Nat Rev Cancer ; 16(11): 718-731, 2016 11.
Article em En | MEDLINE | ID: mdl-27562463
ABSTRACT
The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to produce sterols and isoprenoids that are integral to tumour growth and progression. In recent years, many oncogenic signalling pathways have been shown to increase the activity and/or the expression of MVA pathway enzymes. This Review summarizes recent advances and discusses unique opportunities for immediately targeting this metabolic vulnerability in cancer with agents that have been approved for other therapeutic uses, such as the statin family of drugs, to improve outcomes for cancer patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Redes e Vias Metabólicas / Ácido Mevalônico / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Redes e Vias Metabólicas / Ácido Mevalônico / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article