Memory γδ T Cells-Newly Appreciated Protagonists in Infection and Immunity.
Trends Immunol
; 37(10): 690-702, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27567182
Despite the potential for diversity in their T cell receptor, γδ T cells are primarily considered to be innate immune cells. Recently, memory-like γδ T cell responses have been identified in murine models of infection and autoimmunity. Similar memory responses have also been described in human and non-human primate γδ T cells. It has thus become clear that subpopulations of γδ T cells can develop long-lasting memory akin to conventional αß T cells, with protective and pathogenic consequences. Hence, a re-evaluation of their true capabilities and role in infection and immunity is required. This review discusses recent reports of memory-type responses attributed to γδ T cells and assesses this underappreciated facet of these enigmatic cells.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
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Linfócitos T
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Receptores de Antígenos de Linfócitos T gama-delta
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Memória Imunológica
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Infecções
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article