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A Multicomponent Animal Virus Isolated from Mosquitoes.
Ladner, Jason T; Wiley, Michael R; Beitzel, Brett; Auguste, Albert J; Dupuis, Alan P; Lindquist, Michael E; Sibley, Samuel D; Kota, Krishna P; Fetterer, David; Eastwood, Gillian; Kimmel, David; Prieto, Karla; Guzman, Hilda; Aliota, Matthew T; Reyes, Daniel; Brueggemann, Ernst E; St John, Lena; Hyeroba, David; Lauck, Michael; Friedrich, Thomas C; O'Connor, David H; Gestole, Marie C; Cazares, Lisa H; Popov, Vsevolod L; Castro-Llanos, Fanny; Kochel, Tadeusz J; Kenny, Tara; White, Bailey; Ward, Michael D; Loaiza, Jose R; Goldberg, Tony L; Weaver, Scott C; Kramer, Laura D; Tesh, Robert B; Palacios, Gustavo.
Afiliação
  • Ladner JT; Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. Electronic address: jason.t.ladner.ctr@mail.mil.
  • Wiley MR; Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Beitzel B; Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Auguste AJ; Institute for Human Infections and Immunity, Departments of Pathology, Microbiology & Immunology, and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Dupuis AP; Arbovirus Laboratory, Wadsworth Center, New York State Department of Health, Albany, NY 12159, USA.
  • Lindquist ME; Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Sibley SD; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
  • Kota KP; Molecular and Translational Sciences Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Fetterer D; Research Support Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Eastwood G; Arbovirus Laboratory, Wadsworth Center, New York State Department of Health, Albany, NY 12159, USA.
  • Kimmel D; Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Prieto K; Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Guzman H; Institute for Human Infections and Immunity, Departments of Pathology, Microbiology & Immunology, and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Aliota MT; Arbovirus Laboratory, Wadsworth Center, New York State Department of Health, Albany, NY 12159, USA.
  • Reyes D; Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Brueggemann EE; Molecular and Translational Sciences Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • St John L; Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Hyeroba D; Makerere University, Kampala, Uganda.
  • Lauck M; Wisconsin National Primate Research Center, Madison, WI 53715, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.
  • Friedrich TC; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA; Wisconsin National Primate Research Center, Madison, WI 53715, USA.
  • O'Connor DH; Wisconsin National Primate Research Center, Madison, WI 53715, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.
  • Gestole MC; Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Cazares LH; Molecular and Translational Sciences Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA; Henry M. Jackson Foundation, Bethesda, MD 20817, USA; DoD Biotechnology High Performance Computing Software Applications Institute, Frederick, MD 21702, USA; Telem
  • Popov VL; Institute for Human Infections and Immunity, Departments of Pathology, Microbiology & Immunology, and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Castro-Llanos F; U.S. Naval Medical Research Unit No. 6, Lima, Peru.
  • Kochel TJ; U.S. Naval Medical Research Unit No. 6, Lima, Peru.
  • Kenny T; Molecular and Translational Sciences Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • White B; Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Ward MD; Molecular and Translational Sciences Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Loaiza JR; Centro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología, Ciudad de Panamá, Panamá.
  • Goldberg TL; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA; Makerere University, Kampala, Uganda; Wisconsin National Primate Research Center, Madison, WI 53715, USA.
  • Weaver SC; Institute for Human Infections and Immunity, Departments of Pathology, Microbiology & Immunology, and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Kramer LD; Arbovirus Laboratory, Wadsworth Center, New York State Department of Health, Albany, NY 12159, USA; School of Public Health, State University of New York at Albany, One University Place Rensselaer, East Greenbush, NY 12144, USA.
  • Tesh RB; Institute for Human Infections and Immunity, Departments of Pathology, Microbiology & Immunology, and Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.
  • Palacios G; Center for Genome Sciences, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. Electronic address: gustavo.f.palacios.ctr@mail.mil.
Cell Host Microbe ; 20(3): 357-367, 2016 Sep 14.
Article em En | MEDLINE | ID: mdl-27569558
ABSTRACT
RNA viruses exhibit a variety of genome organization strategies, including multicomponent genomes in which each segment is packaged separately. Although multicomponent genomes are common among viruses infecting plants and fungi, their prevalence among those infecting animals remains unclear. We characterize a multicomponent RNA virus isolated from mosquitoes, designated Guaico Culex virus (GCXV). GCXV belongs to a diverse clade of segmented viruses (Jingmenvirus) related to the prototypically unsegmented Flaviviridae. The GCXV genome comprises five segments, each of which appears to be separately packaged. The smallest segment is not required for replication, and its presence is variable in natural infections. We also describe a variant of Jingmen tick virus, another Jingmenvirus, sequenced from a Ugandan red colobus monkey, thus expanding the host range of this segmented and likely multicomponent virus group. Collectively, this study provides evidence for the existence of multicomponent animal viruses and their potential relevance for animal and human health.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus de RNA / Vírus / Colobus / Culicidae Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus de RNA / Vírus / Colobus / Culicidae Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article