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Synthesis of Substituted 3(2H)-Furanones Using Alkylative Intramolecular Cyclization of Sulfonium Salts.
Inagaki, Sho; Ukaku, Mika; Chiba, Akira; Takahashi, Fumi; Yoshimi, Yasuharu; Morita, Toshio; Kawano, Tomikazu.
Afiliação
  • Inagaki S; Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University , Yahaba, Iwate 028-3694, Japan.
  • Ukaku M; Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University , Yahaba, Iwate 028-3694, Japan.
  • Chiba A; Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University , Yahaba, Iwate 028-3694, Japan.
  • Takahashi F; Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University , Yahaba, Iwate 028-3694, Japan.
  • Yoshimi Y; Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, University of Fukui , 3-9-1 Bunkyo, Fukui 910-8507, Japan.
  • Morita T; Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, University of Fukui , 3-9-1 Bunkyo, Fukui 910-8507, Japan.
  • Kawano T; Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University , Yahaba, Iwate 028-3694, Japan.
J Org Chem ; 81(18): 8363-9, 2016 09 16.
Article em En | MEDLINE | ID: mdl-27570891
ABSTRACT
The facile alkylative intramolecular cyclization of 3-alkoxycarbonyl-2-oxopropyldiphenylsulfonium salts is described. This simple method can be readily applied to the synthesis of a novel family of 4-alkylated 3(2H)-furanones in moderate to high yields under mild conditions via a one-pot process.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article