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Complex Class 1 Integron Carrying qnrB62 and blaVIM-2 in a Citrobacter freundii Clinical Isolate.
Lee, Jae Jin; Kim, Mi-Na; Park, Kwang Seung; Lee, Jung Hun; Karim, Asad Mustafa; Park, Moonhee; Kim, Ji Hwan; Lee, Sang Hee.
Afiliação
  • Lee JJ; National Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin, Gyeonggido, Republic of Korea.
  • Kim MN; Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.
  • Park KS; National Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin, Gyeonggido, Republic of Korea.
  • Lee JH; National Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin, Gyeonggido, Republic of Korea.
  • Karim AM; National Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin, Gyeonggido, Republic of Korea.
  • Park M; National Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin, Gyeonggido, Republic of Korea.
  • Kim JH; DNA Analysis Division, Seoul Institute, National Forensic Service, Yangcheongu, Seoul, Republic of Korea.
  • Lee SH; National Leading Research Laboratory of Drug Resistance Proteomics, Department of Biological Sciences, Myongji University, Yongin, Gyeonggido, Republic of Korea.
Antimicrob Agents Chemother ; 60(11): 6937-6940, 2016 11.
Article em En | MEDLINE | ID: mdl-27572415
ABSTRACT
The coexistence of qnrB62 and blaVIM-2 was detected in a Citrobacter clinical isolate. The reduced fluoroquinolone susceptibility is attributable to qnrB62, mutations of quinolone-resistance-determining regions, and an efflux pump or pumps. The genetic context surrounding chromosomal qnrB62 was a novel complex class 1 integron (In1184ISCR1qnrB62) containing a unique gene array (blaVIM-2-aacA4'-8-gucD). An 18-nucleotide deletion at the 3' end of the pspA gene [pspA(Δ18)], upstream of qnrB62, and an inverted repeat region (IRR2) were detected in In1184ISCR1qnrB62, indicating past transposition events.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Beta-Lactamases / Citrobacter freundii / Farmacorresistência Bacteriana / Antibacterianos Limite: Humans País como assunto: Asia Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Beta-Lactamases / Citrobacter freundii / Farmacorresistência Bacteriana / Antibacterianos Limite: Humans País como assunto: Asia Idioma: En Ano de publicação: 2016 Tipo de documento: Article