Histone H3K27 Trimethylation Modulates 5-Fluorouracil Resistance by Inhibiting PU.1 Binding to the DPYD Promoter.

Wu, Rentian; Nie, Qian; Tapper, Erin E; Jerde, Calvin R; Dunlap, Garrett S; Shrestha, Shikshya; Elraiyah, Tarig A; Offer, Steven M; Diasio, Robert B

Wu, Rentian; Nie, Qian; Tapper, Erin E; Jerde, Calvin R; Dunlap, Garrett S; Shrestha, Shikshya; Elraiyah, Tarig A; Offer, Steven M; Diasio, Robert B.

Afiliação

Wu R; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Cancer Center, Rochester, Minnesota.
Nie Q; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Cancer Center, Rochester, Minnesota.
Tapper EE; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Cancer Center, Rochester, Minnesota.
Jerde CR; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Cancer Center, Rochester, Minnesota.
Dunlap GS; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Cancer Center, Rochester, Minnesota.
Shrestha S; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Cancer Center, Rochester, Minnesota.
Elraiyah TA; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Cancer Center, Rochester, Minnesota.
Offer SM; Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota.
Diasio RB; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Cancer Center, Rochester, Minnesota. diasio.robert@mayo.edu offer.steven1@mayo.edu.

Cancer Res ; 76(21): 6362-6373, 2016 11 01.

Article em En | MEDLINE | ID: mdl-27578004

Assuntos

Di-Hidrouracila Desidrogenase (NADP)/genética; Fluoruracila/farmacologia; Histonas/metabolismo; Regiões Promotoras Genéticas; Proteínas Proto-Oncogênicas/antagonistas & inibidores; Transativadores/antagonistas & inibidores; Resistencia a Medicamentos Antineoplásicos; Proteína Potenciadora do Homólogo 2 de Zeste/fisiologia; Humanos; Metilação; Proteínas Proto-Oncogênicas/metabolismo; Transativadores/metabolismo; Células Tumorais Cultivadas

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Histonas / Transativadores / Proteínas Proto-Oncogênicas / Regiões Promotoras Genéticas / Di-Hidrouracila Desidrogenase (NADP) / Fluoruracila Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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