Solubility enhancement and targeted delivery of a potent anticancer flavonoid analogue to cancer cells using ligand decorated dendrimer nano-architectures.

Luong, Duy; Kesharwani, Prashant; Killinger, Bryan A; Moszczynska, Anna; Sarkar, Fazlul H; Padhye, Subhash; Rishi, Arun K; Iyer, Arun K

Luong, Duy; Kesharwani, Prashant; Killinger, Bryan A; Moszczynska, Anna; Sarkar, Fazlul H; Padhye, Subhash; Rishi, Arun K; Iyer, Arun K.

Afiliação

Luong D; Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, 259 Mack Ave, Wayne State University, Detroit, MI 48201, USA.
Kesharwani P; Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, 259 Mack Ave, Wayne State University, Detroit, MI 48201, USA.
Killinger BA; Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, 259 Mack Ave, Wayne State University, Detroit, MI 48201, USA.
Moszczynska A; Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, 259 Mack Ave, Wayne State University, Detroit, MI 48201, USA.
Sarkar FH; Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, MI 48201, USA.
Padhye S; Interdisciplinary Science & Technology Research Academy, Department of Chemistry, Abeda Inamdar College, Azam Campus, University of Pune, Pune 411001, India.
Rishi AK; John D. Dingell VA Medical Center, Wayne State University, Detroit, MI 48201, USA; Department of Oncology, Wayne State University, Detroit, MI 48201, USA; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, MI 48201, USA.
Iyer AK; Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, 259 Mack Ave, Wayne State University, Detroit, MI 48201, USA; Molecular Therapeutics Program, Barbara Ann Karmanos Ca

J Colloid Interface Sci ; 484: 33-43, 2016 Dec 15.

Article em En | MEDLINE | ID: mdl-27585998

Assuntos

Antineoplásicos Fitogênicos/farmacologia; Curcumina/análogos & derivados; Dendrímeros/química; Portadores de Fármacos/química; Flavonoides/farmacologia; Antineoplásicos Fitogênicos/química; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Curcumina/química; Curcumina/farmacologia; Diarileptanoides; Flavonoides/química; Receptor 1 de Folato/genética; Receptor 1 de Folato/metabolismo; Ácido Fólico/química; Ácido Fólico/metabolismo; Células HeLa; Humanos; Terapia de Alvo Molecular; NF-kappa B/antagonistas & inibidores; NF-kappa B/genética; NF-kappa B/metabolismo; PTEN Fosfo-Hidrolase/genética; PTEN Fosfo-Hidrolase/metabolismo; Solubilidade

Palavras-chave

34-Difluorobenzylidene diferuloylmethane (CDF); Cervical cancer; Flavonoid analogue; Folate receptor targeting; Ovarian cancer; PAMAM dendrimer; Targeted drug delivery

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Flavonoides / Portadores de Fármacos / Curcumina / Dendrímeros / Antineoplásicos Fitogênicos Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google