Biochemical Changes in Erythrocytes as a Molecular Marker of Cell Damage during Long-Term Simvastatin Treatment.
Bull Exp Biol Med
; 161(4): 600-3, 2016 Aug.
Article
em En
| MEDLINE
| ID: mdl-27591878
ABSTRACT
Long-term administration of simvastatin to rats, irrespective of the baseline cholesterol levels, induced biochemical changes in erythrocytes attesting to hypoxic damage (accumulation of lactate and 2,3-diphosphoglycerate), disturbances in ATP-dependent mechanisms of ion homeostasis regulation (decrease in total ATPase and Ca(2+)-ATPase activities), and antioxidant enzymes system imbalance. These changes can be considered as a sensitive indicator and molecular basis of cell damage during long-term administration of statins.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sinvastatina
/
Eritrócitos
Limite:
Animals
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article