Unusual presence of the immune evasion gene cluster in livestock-associated MRSA of lineage CC398 causing peridural and psoas abscesses in a poultry farmer.
Enferm Infecc Microbiol Clin
; 35(10): 651-654, 2017 Dec.
Article
em En, Es
| MEDLINE
| ID: mdl-27592463
ABSTRACT
OBJECTIVE:
To characterize a methicillin-resistant Staphylococcus aureus (MRSA) isolate responsible for an aggressive infection (peridural and psoas abscess secondary to haematogenous septic arthritis) in a poultry farmer.METHODS:
Molecular characterization was performed, including spa- and multilocus sequence typing of the isolate, assessment of its resistance phenotype and detection of tetracycline resistance and of virulence and immune evasion cluster (IEC) genes were performed.RESULTS:
The MRSA isolate was tetracycline- and fluorquinolone-resistant, and was ascribed to CC398, spa-t1451. The isolate harboured tet(M) (distinctive of livestock-associated (LA) MRSA-CC398 clade) and IEC-type B system (characteristic of the methicillin-susceptible human lineage, but typically absent in LA-MRSA-CC398 strains), and lacked toxin-coding genes lukF/lukS-PV, tsst-1, eta and etb.CONCLUSION:
IEC re-acquisition by LA-MRSA-CC398-LA strains is an unusual finding, but could constitute an emerging public health problem. It would represent an evolutionary step towards LA-MRSA-CC398's adaptation to human hosts, and might enhance its invasiveness and ability to be transmitted to humans.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Aves Domésticas
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Espondilite
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Infecções Estafilocócicas
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Artrite Infecciosa
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Abscesso
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Staphylococcus aureus Resistente à Meticilina
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Evasão da Resposta Imune
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Criação de Animais Domésticos
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Meningite
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Doenças Profissionais
Tipo de estudo:
Etiology_studies
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Risk_factors_studies
Limite:
Animals
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Humans
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Male
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Middle aged
Idioma:
En
/
Es
Ano de publicação:
2017
Tipo de documento:
Article