Investigation of precursor lesions of polypoidal choroidal vasculopathy using contralateral eye findings.
Graefes Arch Clin Exp Ophthalmol
; 255(2): 281-291, 2017 Feb.
Article
em En
| MEDLINE
| ID: mdl-27596850
ABSTRACT
PURPOSE:
The purpose was to investigate precursor lesions of polypoidal choroidal vasculopathy (PCV).METHODS:
This cross-sectional study involved 276 unaffected contralateral eyes from unilateral PCV patients (Group 1), unilateral typical exudative age-related macular degeneration (AMD) patients (Group 2), and unilateral epiretinal membrane patients (Group 3) as age-matched controls. Grayish-yellow sub-retinal or sub-retinal-pigment-epithelial deposits larger than 63 µm in size with irregular but discrete margins were defined as drusen-like deposits (DLDs). The frequencies of DLDs, drusen, and pigmentary changes in each group were compared.RESULTS:
DLDs larger than 125 µm in size were found more frequently in Group 1 (19.5 %) than in Groups 2 (3.4 %) and 3 (3.2 %) (p < 0.001). Soft drusen were discovered more frequently in Group 2 eyes than in Groups 1 and 3 (p < 0.001). Pigmentary changes were found more frequently in Groups 1 and 2 compared to Group 3. Compared with the other groups, Group 1 manifested a higher frequency of choroidal vascular hyperpermeability (p < 0.005) and thicker choroid (p < 0.001).CONCLUSIONS:
The precursor lesions of PCV are different from those of exudative AMD. DLDs larger than 125 µm and pigmentary changes may be early preclinical markers of PCV. Long-term longitudinal studies are warranted for validation.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pólipos
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Angiofluoresceinografia
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Corioide
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Neovascularização de Coroide
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Epitélio Pigmentado da Retina
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article