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Four new taraxastane-type triterpenoic acids from Cirsium setosum.
Luan, Na; Wei, Wen-Di; Wang, Ali; Wu, Xiu-Li; Qi, Yan; Li, Jin-Jie; Zheng, Jian-Quan; Shang, Xiao-Ya.
Afiliação
  • Luan N; a Beijing Key Laboratory of Bioactive Substances and Functional Foods , Beijing Union University , Beijing 100191 , China.
  • Wei WD; a Beijing Key Laboratory of Bioactive Substances and Functional Foods , Beijing Union University , Beijing 100191 , China.
  • Wang A; a Beijing Key Laboratory of Bioactive Substances and Functional Foods , Beijing Union University , Beijing 100191 , China.
  • Wu XL; b College of Pharmacy , Ningxia Medical University , Yinchuan 750004 , China.
  • Qi Y; c Beijing Municipal Bureau of City Administration and Law Enforcement , Beijing 101500 , China.
  • Li JJ; a Beijing Key Laboratory of Bioactive Substances and Functional Foods , Beijing Union University , Beijing 100191 , China.
  • Zheng JQ; a Beijing Key Laboratory of Bioactive Substances and Functional Foods , Beijing Union University , Beijing 100191 , China.
  • Shang XY; a Beijing Key Laboratory of Bioactive Substances and Functional Foods , Beijing Union University , Beijing 100191 , China.
J Asian Nat Prod Res ; 18(11): 1015-23, 2016 Nov.
Article em En | MEDLINE | ID: mdl-27598298
ABSTRACT
Four new taraxastane-type triterpenoids acids 3ß,22α-dihydroxy-20-taraxasten-30-oic acid (1), 3ß-hydroxy-22-oxo-20-taraxasten-30-oic acid (2), 3-oxo-22α-hydroxy-20- taraxasten-30-oic acid (3), and 3ß,19ß-dihydroxy-20-taraxasten-30-oic acid (4) were isolated and characterized from Cirsium setosum (Willd.) MB. Their structures were determined by the combination of 1D and 2D NMR experiments ((1)H-(1)HCOSY, HSQC, HMBC and ROESY) and mass spectrometry. Compound 2 exhibited potent selective cytotoxicity against human ovarian cancer cell line A2780 with an IC50 value of 3.9 µM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triterpenos / Cirsium Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triterpenos / Cirsium Limite: Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article