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Ceftriaxone-Resistant Neisseria gonorrhoeae Isolates (2010 to 2014) in France Characterized by Using Whole-Genome Sequencing.
de Curraize, Claire; Kumanski, Sylvain; Micaëlo, Maïté; Fournet, Nelly; La Ruche, Guy; Meunier, Fabienne; Amarsy, Rishma; Jacquier, Hervé; Cambau, Emmanuelle; Goubard, Agathe; Bercot, Béatrice.
Afiliação
  • de Curraize C; Laboratory of Bacteriology, University Hospital of Dijon, Dijon, France.
  • Kumanski S; APHP, Lariboisière-St Louis-Fernand Widal Hospital, Laboratory of Bacteriology, Associated Laboratory for the National Reference Centre for Gonococci, Paris, France.
  • Micaëlo M; APHP, Lariboisière-St Louis-Fernand Widal Hospital, Laboratory of Bacteriology, Associated Laboratory for the National Reference Centre for Gonococci, Paris, France.
  • Fournet N; APHP, Lariboisière-St Louis-Fernand Widal Hospital, Laboratory of Bacteriology, Associated Laboratory for the National Reference Centre for Gonococci, Paris, France.
  • La Ruche G; University Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, Paris, France.
  • Meunier F; INSERM, IAME, UMR 1137, Paris, France.
  • Amarsy R; French Institute for Public Heath Surveillance (InVS), Department of Infectious Diseases, Saint-Maurice, France.
  • Jacquier H; French Institute for Public Heath Surveillance (InVS), Department of Infectious Diseases, Saint-Maurice, France.
  • Cambau E; APHP, Lariboisière-St Louis-Fernand Widal Hospital, Laboratory of Bacteriology, Associated Laboratory for the National Reference Centre for Gonococci, Paris, France.
  • Goubard A; APHP, Lariboisière-St Louis-Fernand Widal Hospital, Laboratory of Bacteriology, Associated Laboratory for the National Reference Centre for Gonococci, Paris, France.
  • Bercot B; University Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité, Paris, France.
Antimicrob Agents Chemother ; 60(11): 6962-6964, 2016 11.
Article em En | MEDLINE | ID: mdl-27600036
ABSTRACT
Two extended-spectrum cephalosporin-resistant Neisseria gonorrhoeae isolates were discovered among 6,340 (0.03%) French isolates between 2010 and 2014. One isolate corresponded to the F89 multidrug-resistant N. gonorrhoeae isolate harboring a penA mosaic; whole-genome sequencing highlighted an additional R251H substitution in the ftsX gene recently involved in cephalosporin resistance. The other, ceftriaxone-resistant isolate (MIC, 0.25 mg/liter) harbored the PBP2 pattern XXXVI plus a P551S substitution and belonged to sequence type ST1579 (multilocus sequence typing [MLST]).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ceftriaxona / Resistência às Cefalosporinas / Neisseria gonorrhoeae Limite: Humans País como assunto: Europa Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ceftriaxona / Resistência às Cefalosporinas / Neisseria gonorrhoeae Limite: Humans País como assunto: Europa Idioma: En Ano de publicação: 2016 Tipo de documento: Article