Inhibition of Cytochrome P450 2B6 Activity by Voriconazole Profiled Using Efavirenz Disposition in Healthy Volunteers.

Desta, Zeruesenay; Metzger, Ingrid F; Thong, Nancy; Lu, Jessica B L; Callaghan, John T; Skaar, Todd C; Flockhart, David A; Galinsky, Raymond E

Desta, Zeruesenay; Metzger, Ingrid F; Thong, Nancy; Lu, Jessica B L; Callaghan, John T; Skaar, Todd C; Flockhart, David A; Galinsky, Raymond E.

Afiliação

Desta Z; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA zdesta@iu.edu.
Metzger IF; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Thong N; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Lu JB; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Callaghan JT; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Skaar TC; Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana, USA.
Flockhart DA; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Galinsky RE; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Antimicrob Agents Chemother ; 60(11): 6813-6822, 2016 11.

Article em En | MEDLINE | ID: mdl-27600044

Assuntos

Benzoxazinas/farmacocinética; Inibidores do Citocromo P-450 CYP2B6/farmacologia; Citocromo P-450 CYP2B6/sangue; Voriconazol/farmacologia; Administração Oral; Adolescente; Adulto; Alcinos; Ciclopropanos; Inibidores do Citocromo P-450 CYP2B6/administração & dosagem; Inibidores do Citocromo P-450 CYP2B6/farmacocinética; Feminino; Voluntários Saudáveis; Humanos; Inativação Metabólica; Masculino; Pessoa de Meia-Idade; Voriconazol/administração & dosagem; Voriconazol/farmacocinética; Adulto Jovem

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzoxazinas / Voriconazol / Citocromo P-450 CYP2B6 / Inibidores do Citocromo P-450 CYP2B6 Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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