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The Oncolytic Efficacy and in Vivo Pharmacokinetics of [2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol (Vacquinol-1) Are Governed by Distinct Stereochemical Features.
Hammarström, Lars G J; Harmel, Robert K; Granath, Mikael; Ringom, Rune; Gravenfors, Ylva; Färnegårdh, Katarina; Svensson, Per H; Wennman, David; Lundin, Göran; Roddis, Ylva; Kitambi, Satish S; Bernlind, Alexandra; Lehmann, Fredrik; Ernfors, Patrik.
Afiliação
  • Hammarström LG; Glionova Therapeutics , Västra Trädgårdsgatan 15, SE-111 53 Stockholm, Sweden.
  • Granath M; OnTargetChemistry AB , Virdings Allé 18, SE-754 50 Uppsala, Sweden.
  • Ringom R; OnTargetChemistry AB , Virdings Allé 18, SE-754 50 Uppsala, Sweden.
  • Gravenfors Y; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Organic Chemistry, Stockholm University , Box 1030, SE-171 21 Solna, Sweden.
  • Färnegårdh K; Drug Discovery and Development Platform, Science for Life Laboratory, Department of Organic Chemistry, Stockholm University , Box 1030, SE-171 21 Solna, Sweden.
  • Svensson PH; SP Process Development , Forskargatan 20J, SE-151 36 Södertälje, Sweden.
  • Wennman D; SP Process Development , Forskargatan 20J, SE-151 36 Södertälje, Sweden.
  • Lundin G; SP Process Development , Forskargatan 20J, SE-151 36 Södertälje, Sweden.
  • Roddis Y; SP Process Development , Forskargatan 20J, SE-151 36 Södertälje, Sweden.
  • Bernlind A; SP Process Development , Forskargatan 20J, SE-151 36 Södertälje, Sweden.
  • Lehmann F; OnTargetChemistry AB , Virdings Allé 18, SE-754 50 Uppsala, Sweden.
J Med Chem ; 59(18): 8577-92, 2016 09 22.
Article em En | MEDLINE | ID: mdl-27607569
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Quinolinas / Neoplasias Encefálicas / Glioblastoma / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Quinolinas / Neoplasias Encefálicas / Glioblastoma / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2016 Tipo de documento: Article